西部中医药2025，Vol.38Issue(7)：1-5,5.DOI:10.12174/j.issn.2096-9600.2025.07.01
基于减毒增效目的探讨复方雷公藤汤最佳制备工艺
The Optimum Preparation Process of Compound Leigongteng Decoction Based on Toxicity Reducing and Efficacy Enhancing
摘要
Abstract
Objective:To explore the toxicity-reducing and efficacy-enhancing effects of the orthogonal design of the optimum preparation process of compound Leigongteng(Tripterygium wilfordii Hook.f.)decoction on the liver of nephrotic rats.Methods:After replicating the nephropathy models,the model were randomized into nine groups with ten in each,and they were drenched with the decoction prepared by different methods for 20 days continuously.To detect 24-hour urine total protein quantity(24 hUTP),the levels of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase of the rats,and to screen the optimum preparation process of compound Leigongteng decoction.Results:The factors influencing hepatotoxicity ranked in the descending order:the time of Leigongteng decocting first>decocting time>soaking time>water addition.The factors influencing 24 hUTP showed in the descending order:the time of Leigongteng decocting first>decocting time>water addition>soaking time,and no influence was found in soaking time.Conclusion:When compound Leigongteng decoction in the treatment of nephropathy is used to reduce liver toxicity,A3B2C1D3 boiling process is adopted;when it is applied to lower 24hUTP,it's appropriate to adopt A1B3C3D3 boiling process,the two kinds of processes could reduce the toxicity and enhance clinical effects.关键词
复方雷公藤汤/制备工艺/正交设计/肾病大鼠/肝脏/实验研究Key words
compound Leigongteng decoction/preparation process/the orthogonal design/nephrotic rats/liver/experimental study分类
医药卫生引用本文复制引用
李闻音,李波,金伶佳,吴美兰..基于减毒增效目的探讨复方雷公藤汤最佳制备工艺[J].西部中医药,2025,38(7):1-5,5.基金项目
国家自然科学基金(81250027). （81250027）
