西部中医药2025，Vol.38Issue(7)：12-17,6.DOI:10.12174/j.issn.2096-9600.2025.07.03
复方扶芳藤合剂作为治疗性和预防性给药的选择研究
Study on Selection of Compound Fufangteng Mixture for Therapeutic and Preventive Administration
摘要
Abstract
Objective:To investigate the best method of compound Fufangteng mixture(CFM)given through therapeutic or preventive administration to the mice with cyclophosphamide(CTX)induced immunosuppression.Methods:BALB/c mice were randomized into the blank group(Blank),the treatment groups of high,moderate and low doses of CTX+CFM(CTX+CFM-1,2,3),and the prevention groups of high,moderate and low doses of CFM+CTX(CFM+CTX-1,2,3),five mice in each group.Physiological saline was administered to Blank group through peritoneal injection(0.02 mL/g),CTX+CFM-1,2 and 3 were given 70 mg/kg CTX by intraperitoneal injection,once each day,for three days in a row,from the 4th day,the three groups were given 15 g/kg,7.5 g/kg and 3.75 g/kg CFM,for ten consecutive days.CFM+CTX-1,2 and 3 were drenched with 15 g/kg,7.5 g/kg and 3.75 g/kg CFM for ten days continuously,three groups accepted intraperitoneal injection of 70 mg/kg CTX since the 11th day,once each day,for three days consecutively.To observe the state of the mice,to monitor the body weight,and to detect routine blood test,spleen index and the proportions of T lymphocytes in mice.Results:No significant difference has been found in the improvements of body weights,spleen indexes,and the proportions of T lymphocytes in mice with CTX-induced immunosuppression between the prevention groups of CFM+CTX and the treatment groups of CTX+CFM(P>0.05),while the treatment groups of CTX+CFM was obviously better than the prevention groups of CFM+CTX in improving thymus index and the lymphocytes count in immunosuppres-sion mice(P<0.05).Conclusion:CFM as preventive administration is more beneficial to improve the immune state of CTX-induced immunosuppressed mice.关键词
复方扶芳藤合剂/免疫抑制/T淋巴细胞Key words
compound Fufangteng mixture/immunosuppression/T lymphocytes分类
医药卫生引用本文复制引用
陈果,刘显,彭丽珊,李建明,吴展帅,肖健..复方扶芳藤合剂作为治疗性和预防性给药的选择研究[J].西部中医药,2025,38(7):12-17,6.基金项目
国家自然科学基金(81860780) （81860780）
国家自然科学基金地区基金(82460863) （82460863）
广西自然科学基金(2020GXNSFAA297162) （2020GXNSFAA297162）
广西自然科学基金青年科学基金(2020GXNSFBA159064) （2020GXNSFBA159064）
2018年广西中医药大学校级课题(2018QN028) （2018QN028）
2018年广西博士科研启动金(2018BS015). （2018BS015）
