广州化学2025，Vol.50Issue(4)：40-44,5.DOI:10.16560/j.cnki.gzhx.20250412
草木灰水浸提液促进2,3-二芳基喹喔啉的绿色合成
Green Synthesis of 2,3-Diarylquinoxaline Promoted by Water-extracting Solution of Plant Ash
摘要
Abstract
Water-extracting solution was obtained by simply extracting plant ash,a waste from biomass.The solution can act as both a green solvent and catalyst to promote efficient synthesis of 2,3-diaryl quinoxalines from benzils and o-phenylenediamines,and the yields range from 64%to 92%.Reactions were generally completed within about two hours.After reactions,relatively pure products were achieved by simple filtration without any other workup such as extraction,recrystallization and chromatography.Furthermore,the aqueous filtrate can be straight recycled in the next reaction,which means that no wastes were produced in the whole reaction and workup process.Yields were not reduced apparently after five-time-recycling of the filtrate.Under the same conditions,the reaction of benzil with o-phenylenediamine to generate 2,3-diphenylquinoxaline has a yield of 62%with many other impurities.The optimized reaction conditions were as follows:molar ratio n(benzils):n(o-phenylenediamines)=1:1;volume ratio v(water-extracting solution):v(ethanol)=10:1;reaction temperature 80℃;reaction time 2 h.Our synthetic method was almost"overall"green synthesis,and environmental factor(EF)was calculated to be 2.45,a value far lower than common fine chemicals and pharmaceuticals.This green,simple,practical and cost-saving method is expected to be applied extensively in synthesis of substituted quinoxalines.关键词
二芳基喹喔啉/草木灰/绿色合成/循环利用/生物质Key words
diaryl quinoxaline/plant ash/green synthesis/recycling/biomass分类
化学化工引用本文复制引用
郭艾琰,黄堃艳,韦超,陈红云,熊振华,程传杰..草木灰水浸提液促进2,3-二芳基喹喔啉的绿色合成[J].广州化学,2025,50(4):40-44,5.基金项目
江西省自然科学基金(2009GZH0035) （2009GZH0035）
江西科技师范大学本科生创新科研项目 （）
