海南医科大学学报2025，Vol.31Issue(15)：1189-1200,12.DOI:10.13210/j.cnki.jhmu.20250520.003
中药调控BDNF/Trk B信号通路治疗缺血性脑卒中的研究进展
Research progress on traditional Chinese medicine regulating the BDNF/Trk B signaling pathway in the treatment of ischemic stroke
摘要
Abstract
Ischemic stroke(IS)is a major neurological disorder characterized by high disability and mortality rates.Current treatments,such as endovascular mechanical thrombectomy and intravenous thrombolysis,face challenges including limited effica-cy and narrow therapeutic time windows.In recent years,traditional Chinese medicine(TCM)has emerged as a research hotspot for IS treatment due to its natural multi-target properties.The brain-derived neurotrophic factor(BDNF)/tropomyosin receptor ki-nase B(Trk B)signaling pathway plays a pivotal role in neurogenesis,synaptic plasticity,neuroprotection,and angiogenesis,making it a key pathway for regulating neurological recovery.Extensive studies indicate that the BDNF/Trk B pathway is critically involved in the pathogenesis and progression of IS.Its activation promotes neural repair,reduces apoptosis,enhances synaptic plasticity,and stimulates cerebral angiogenesis.TCM,by modulating the BDNF/Trk B pathway to exert neuroprotective effects,has become a promising direction for exploring novel IS therapies.This article reviews the mechanisms of the BDNF/Trk B path-way in IS,analyzes recent advances in TCM-mediated regulation of this pathway for IS treatment,and discusses the potential of TCM formulations and their active components in alleviating IS symptoms and promoting neurological recovery.Through system-atic analysis,this review provides theoretical foundations and references for future applications of TCM in IS treatment,as well as new strategies and insights for clinical practice.关键词
缺血性脑卒中/BDNF/Trk B/信号通路/研究进展Key words
Ischemic stroke/BDNF/Trk B/Signaling pathway/Research progress分类
医药卫生引用本文复制引用
包璇,金华,杜婕,刘杰..中药调控BDNF/Trk B信号通路治疗缺血性脑卒中的研究进展[J].海南医科大学学报,2025,31(15):1189-1200,12.基金项目
This study was supported by the National Natural Science Foundation of China Regional Funded Project(82160886),Key Talent Project of Gansu Province(2023RCXM28),and Science and Technology Plan Project of Gansu Province(23JRRA1524) 国家自然科学基金地区基金资助项目(82160886) （82160886）
甘肃省省级重点人才项目(2023RCXM28) （2023RCXM28）
甘肃省省级科技计划项目(23JR-RA1524) （23JR-RA1524）
