实用临床医药杂志2025，Vol.29Issue(13)：39-43,49,6.DOI:10.7619/jcmp.20245782
干果摄入与结直肠癌风险的关系:一项两样本孟德尔随机化研究
Relationship between dried fruit intake and risk of colorectal cancer:a two-sample Mendelian randomization study
摘要
Abstract
Objective To investigate the causal relationship between dried fruit intake and color-ectal cancer(CRC)by using a two-sample Mendelian randomization(MR)approach.Methods Two-sample MR analysis was conducted utilizing summary data from genome-wide association studies on dried fruit intake and colorectal cancer.Separate analyses were performed using data for colon cancer and rectal cancer for validation.Genetic variants significantly and independently associated with dried fruit intake were selected as instrumental variables.The inverse variance weighted method,MR-Egger regression,weighted median method,simple mode method,and weighted mode method were employed as the primary analytical approaches.Heterogeneity tests,pleiotropy analysis,and sensitivity analysis were conducted to evaluate the reliability of the study.Results A total of 21 single nucleotide poly-morphisms(SNPs)associated with dried fruit intake were included as instrumental variables.The in-verse variance weighted analysis revealed that increased dried fruit intake was associated with a reduced risk of colorectal cancer(OR=0.55,95％CI,0.32 to 0.96,P=3.53 × 10-2),with consistent results observed for both colon cancer and rectal cancer.The findings of this study were not influenced by plei-otropy or heterogeneity,and the reliability of the results was validated by sensitivity analysis.Conclu-sion Increasing dried fruit intake has potential preventive value against colorectal cancer.关键词
干果摄入/结直肠癌/孟德尔随机化/全基因组关联分析/因果关系/疾病风险/逆方差加权法/加权中位数法Key words
dried fruit intake/colorectal cancer/Mendelian randomization/genome-wide as-sociation analysis/causal relationship/disease risk/inverse variance weighted method/weighted me-dian method分类
医药卫生引用本文复制引用
金志超,戴虹,杨冉..干果摄入与结直肠癌风险的关系:一项两样本孟德尔随机化研究[J].实用临床医药杂志,2025,29(13):39-43,49,6.基金项目
国家自然科学基金资助项目(81904110) （81904110）
江苏省科技厅青年基金资助项目(BK20191086) （BK20191086）
江苏省中医院高峰学术人才培养工程(y2021rc46) （y2021rc46）
江苏省中医院院级课题(Y22005) （Y22005）
