实用临床医药杂志2025，Vol.29Issue(13)：44-49,6.DOI:10.7619/jcmp.20250245
胃癌组织中膜棕榈酰化蛋白7表达与临床病理特征及预后的关系
Relationships of expression of membrane palmitoylated protein 7 in gastric cancer tissues with clinicopathological features and prognosis
摘要
Abstract
Objective To investigate the relationships of expression of membrane palmitoylated protein 7(MPP7)in gastric cancer(GC)tissues with clinicopathological features and prognosis.Methods A total of 213 GC patients in the hospital from March 2018 to April 2020 were selected as research objects,and their tumor tissues and adjacent non-tumor tissues were collected.Immunohisto-chemistry(IHC)was used to detect the protein expression level of MPP7 in the tumor tissues and ad-jacent non-tumor tissues of GC patients,and the relationship between MPP7 and clinicopathological features was analyzed.The Kaplan-Meier survival curve was used to analyze the relationship between MPP7 expression and prognosis of GC patients.Univariate and multivariate Cox regression analyses were used to explore the relevant factors influencing the prognosis of GC patients.Results Compared with adjacent non-tumor tissues,MPP7 protein was significantly highly expressed in GC tissues(P＜0.05).Among GC patients,those with high MPP7 expression had significantly higher ratios of lymph node metastasis,Ⅲ to Ⅳ stages of cTNM staging,poor differentiation,and muscular layer invasion compared with those with low MPP7 expression(P＜0.001).Among the 156 patients with high MPP7 expression,the survival rate was 8.33％(13/156);among 57 patients with low MPP7 expression,the survival rate was 52.63％(30/57).The results of the Kaplan-Meier survival curve showed a significant difference in survival rates between the high MPP7 expression patients and the low MPP7 expression patients(Log-rank x2=54.333,P＜0.001).Compared with GC patients in the survival group,those in the death group had significantly higher ratios of lymph node metastasis,Ⅲ to Ⅳ stages of cTNM staging,poor differentiation,muscular layer invasion,and high MPP7 expression(P＜0.001).The results of multivariate Cox regression analysis showed that lymph node metastasis,Ⅲ to Ⅳ stages of cTNM staging,poor differentiation,muscular layer invasion,and high MPP7 expres-sion were all risk factors influencing the prognosis of GC patients(P＜0.05).Conclusion High MPP7 expression is closely related to the clinicopathological features and prognosis of GC patients,and it may serve as a potential biomarker for predicting GC progression and poor prognosis.关键词
胃癌/膜棕榈酰化蛋白7/临床病理特征/预后/免疫组织化学法/淋巴结转移/分化程度/总生存期Key words
gastric cancer/membrane palmitoylated protein 7/clinicopathological features/prognosis/immunohistochemistry/lymph node metastasis/degree of differentiation/overall survival分类
医药卫生引用本文复制引用
张涛林,钱正宇,李兴..胃癌组织中膜棕榈酰化蛋白7表达与临床病理特征及预后的关系[J].实用临床医药杂志,2025,29(13):44-49,6.基金项目
2020年四川省医学(青年创新)科研项目(S202957) （青年创新）
