实用临床医药杂志2025，Vol.29Issue(14)：23-27,33,6.DOI:10.7619/jcmp.20250857
特瑞普利单抗联合放化疗对鼻咽癌颈部淋巴结转移及免疫功能的影响
Effect of toripalimab combined with chemoradiotherapy in treatment of cervical lymph node metastasis of nasopharyngeal carcinoma and immune function
摘要
Abstract
Objective To investigate the effect of toripalimab combined with chemoradiotherapy in patients with cervical lymph node metastasis of nasopharyngeal carcinoma on immune function.Methods A prospective study was conducted in 160 patients with nasopharyngeal carcinoma accom-panied by cervical lymph node metastasis.Patients were divided into study group and control group using block randomization,with 80 patients in each group.The control group received a standard che-moradiotherapy regimen,while the study group received toripalimab combined with chemoradiothera-py.Both groups were treated for 3 courses.The clinical efficacy,levels of immune function indica-tors,levels of tumor markers[squamous cell carcinoma antigen(SCC-Ag),high-mobility group box 1(HMGB1),pentraxin 3(PTX3),and cytokeratin 19 fragment antigen 21-1(CYFRA21-1)],and the incidenceof adverse reactions were compared between the two groups.Results The objective re-sponse rates of the primary lesion and cervical lymph nodes in the study group were higher than those in the control group(P＜0.05).After treatment,the levels of CD3+,CD4+,and natural killer cells in the study group were higher than those before treatment and in the control group,while the lev-el of CD8+was lower than that before treatment and in the control group(P＜0.05).After treatment,the levels of HMGB1,PTX3,SCC-Ag and CYFRA21-1 in the study group were lower than those before treatment and in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Toripalimab combined with chemoradiotherapy has a sig-nificant efficacy in treatment of cervical lymph node metastasis of nasopharyngeal carcinoma.It can enhance the immune function of patients,improve the levels of tumor markers,and has good safety.关键词
鼻咽癌/颈部淋巴结转移/特瑞普利单抗/放化疗/免疫功能/肿瘤标志物/客观缓解率/不良反应Key words
nasopharyngeal carcinoma/cervical lymph node metastasis/toripalimab/che-moradiotherapy/immune function/tumor marker/objective response rate/adverse reaction分类
医药卫生引用本文复制引用
刘东阳,蔡梦娇,何丽,李迎..特瑞普利单抗联合放化疗对鼻咽癌颈部淋巴结转移及免疫功能的影响[J].实用临床医药杂志,2025,29(14):23-27,33,6.基金项目
陕西省卫生健康委科研项目(2021SF-1062) （2021SF-1062）
