实用临床医药杂志2025，Vol.29Issue(14)：39-44,6.DOI:10.7619/jcmp.20246087
免疫细胞与过敏性鼻炎的因果关系:一项两样本双向孟德尔随机化研究
Causal relationship between immune cells and allergic rhinitis:a two-sample bidirectional mendelian randomization
摘要
Abstract
Objective To explore the causal association between immune cells and allergic rhi-nitis using Mendelian randomization(MR)approach.Methods GWAS data for 731 types of im-mune cells and allergic rhinitis were obtained from genome-wide association study(GWAS)databas-es.A two-sample bidirectional MR analysis was conducted,with the inverse-variance weighted(IVW)method as the primary analytical approach,and the weighted median method,MR-Egger re-gression,simple mode method,and weighted mode method as supplementary approaches.Sensitivity analyses,including heterogeneity tests,pleiotropy tests,and the leave-one-out method,were per-formed.Bonferroni correction was applied to the preliminary results to enhance their reliability and rigor.Results The two-sample forward MR analysis revealed correlations between 67 immune cell phenotypes and allergic rhinitis.After Bonferroni correction,four immune cell phenotypes were finally identified.Among them,the expression of CD3 on CD39-positive activated CD4 regulatory T cells(OR=0.953,95％CI,0.931 to 0.978,P＜0.001,Padj=0.007),the expression of herpesvirus entry mediator(HVEM)on CD45RA-negative CD4+T cells(OR=0.965,95％CI,0.948 to 0.983,P＜0.001,Padj=0.008),and the percentage of human leukocyte antigen class DR(HLA-DR)-high-expressing monocytes among leukocytes(OR=0.929,95％CI,0.885 to 0.974,P=0.002,Padj=0.157)were protective factors for allergic rhinitis.In contrast,the percentage of transitional B cells among B cells(OR=1.094,95％CI,1.032 to 1.161,P=0.003,Padj=0.183)was a risk factor for allergic rhinitis.The reverse MR analysis showed no causal relationship between allergic rhinitis and the four immune cell phenotypes.Conclusion The two-sample forward MR analysis confirms a caus-al link between immune cells and allergic rhinitis.MR analysis has the advantages of reducing con-founding factor interference and avoiding reverse causation,providing a theoretical basis for in-depth research on immune mechanisms,sensitive biomarkers,and drug treatment targets of allergic rhinitis.关键词
孟德尔随机化/免疫细胞/过敏性鼻炎/因果关系/全基因组关联研究/敏感生物标志物/保护因素/危险因素Key words
Mendelian randomization/immune cells/allergic rhinitis/causal relationship/genome-wide association study/sensitive biomarkers/protective factors/risk factors分类
医药卫生引用本文复制引用
位式祥,王成祥,于会勇,李磊,刘莲莲,聂天旸,谢楚溪,解子乐,柯殷泽,陈天韵..免疫细胞与过敏性鼻炎的因果关系:一项两样本双向孟德尔随机化研究[J].实用临床医药杂志,2025,29(14):39-44,6.基金项目
国家自然科学基金资助项目(82074389) （82074389）
首都卫生发展科研专项基金资助项目(首发2022-2-7034) （首发2022-2-7034）
