军事医学2025，Vol.49Issue(7)：513-518,6.DOI:10.7644/j.issn.1674-9960.2025.07.005
晕动病大鼠习服模型建立及行为学探究
Establishment of a model of acclimatization to motion sickness and behavioral investigation in rats
黄靖 1朱晓全 1陈珊 1刘新月 2毛菁钰 1田大为 1常世杰3
作者信息
- 1. 空军特色医学中心,北京 100142
- 2. 空军特色医学中心,北京 100142||95838部队,呼和浩特 010010
- 3. 中国医科大学,沈阳 110122
- 折叠
摘要
Abstract
Objective To establish a rat model of acclimatization to motion sickness(MS)induced by rotational stimulation.Methods To determine the stimulation conditions of MS,SD rats were divided into a static control group(SCG)and a single rotation stimulation group(SRG)before being subjected to the motion sickness index(MSI)measurement,open-field experiment and Morris water maze experiment after rotational stimulation to verify the feasibility of MS being induced in rats.Morris water maze experiments were performed to find out whether rotational stimulation could be used to induce MS in rats.During experiments on acclimatization,the SD rats were divided into the control group(Ctrl),one day of rotational stimulation group(Day1),three days of continuous rotational stimulation group(Day3),and seven days of continuous rotational stimulation group(Day7)before the changes in the MSI and behavior of these rats were recorded so as to explore the relationship between continuous stimulation and MS acclimatization in rats.Results After rotational stimulation,the rats showed a significant increase in the number of fecal pellets(P<0.0001)and in the MSI(P<0.0001)compared with the SCG.In the open field experiment,the rats showed a significant decrease in the spontaneous activity time(AT)(P<0.0001),total spontaneous activity distance(TD)(P<0.001)and distance moved by the center point per second(DMCPS)(P<0.001).The time taken to climb onto the platform(latency to find the platform,LP)(P<0.0001)and the total distance to the platform(distance to the platform,DP)(P<0.001)were significantly increased during the Morris water maze experiment.Acclimatization experiments revealed a significant increase in MSI and in the number of fecal pellets in the Day1 and Day3 groups of rotational stimulation compared to the Ctrl group(P<0.0001).AT(P<0.01),TD(P<0.05)and DMCPS(P<0.01)were significantly decreased,while LP and DP were significantly increased(P<0.0001),but there was no statistically significant difference in indices compared with the Day7 group(P>0.05).Conclusion Sinusoidal stimulation can induce MS in rats,and twice-a-day,continuous rotational stimulation for seven days can lead to acclimatization.The rat MS model can be assessed via behavioral experiments.关键词
晕动病/动物模型/大鼠/旷场实验/Morris水迷宫实验/习服Key words
motion sickness/animal model/rats/open-field experiment/Morris water maze experiment/acclimatization分类
医药卫生引用本文复制引用
黄靖,朱晓全,陈珊,刘新月,毛菁钰,田大为,常世杰..晕动病大鼠习服模型建立及行为学探究[J].军事医学,2025,49(7):513-518,6.
