解放军医学院学报2025，Vol.46Issue(3)：262-270,278,10.DOI:10.12435/j.issn.2095-5227.2025.24122503
口腔菌群与银屑病关系的两样本双向孟德尔随机化研究
Oral microbiome and psoriasis:A two-sample bidirectional mendelian randomization study
摘要
Abstract
Background Studies have found that there is relationship between intestinal flora and the occurrence of psoriasis,but the causal relationship between oral flora and psoriasis is not clear.Objective To explore the relationship between the oral microbiome and psoriasis using two-sample Mendelian randomization method.Methods Single nucleotide polymorphism(SNP)data for oral microbiome exposure and psoriasis outcomes were sourced from China National GeneBank DataBase and NHGRI-EBI GWAS Catalog.MR analysis was conducted using five regression models:MR-Egger,weighted median,inverse variance weighted(IVW),simple,and weighted models.Cochran's Q test,MR-PRESSO,and MR-Egger intercept were used to assess horizontal pleiotropy and heterogeneity.Results This study revealed that Streptococcus infantis.1655(OR=1.347,P=0.005)and Veillonella.1075(OR=1.243,P=0.009)were positively correlated with psoriasis.In contrast,Pauljensenia.1019(OR=0.767,P=0.039),Pseudopropionibacterium.291(OR=0.769,P=0.036),Centipeda.389(OR=0.797,P=0.006),an unclassified microbiota.3196(OR=0.799,P=0.008),and Streptococcus pseudopneumoniae.G.1360(OR=0.833,P=0.034)were negatively correlated with psoriasis.Conclusion Veillonella.1075 increases the risk of psoriasis,while Pauljensenia.1019,Pseudopropionibacterium.291,and Centipeda.389 reduce the risk of psoriasis,however,they show no reverse causal relationship with psoriasis.关键词
口腔菌群/银屑病/孟德尔随机化研究/流行病学/全基因组关联研究Key words
oral microbiota/psoriasis/mendelian randomization/epidemiology/genome-wide association studies分类
医药卫生引用本文复制引用
苏清,王婧宇,马冠毅,刘承灵,梁小强,宋翠豪,孙玉发,赵华..口腔菌群与银屑病关系的两样本双向孟德尔随机化研究[J].解放军医学院学报,2025,46(3):262-270,278,10.基金项目
北京市自然科学基金项目(7244298) （7244298）
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