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继发性免疫功能低下患者HBV、HCV、HIV感染筛查情况分析

张琦马兴焕王鹏杨江存杜春红李喜莹秦莉宫济武夏荣桂嵘刘娟张俊周璐洁刘凤华吕先萍胡俊华周俊

临床输血与检验2025，Vol.27Issue(4)：478-483,6.

临床输血与检验2025，Vol.27Issue(4)：478-483,6.DOI:10.3969/j.issn.1671-2587.2025.04.007

继发性免疫功能低下患者HBV、HCV、HIV感染筛查情况分析

Analysis of Screening for HBV,HCV and HIV Infections in Patientswith Secondary Immunodeficiency

张琦 ¹马兴焕 ²王鹏 ³杨江存 ⁴杜春红 ⁵李喜莹 ⁶秦莉 ⁷宫济武 ⁸夏荣 ¹桂嵘 ⁹刘娟 ²张俊 ¹周璐洁 ¹刘凤华 ¹⁰吕先萍 ¹¹胡俊华 ⁸周俊²

作者信息

1. 复旦大学附属华山医院输血科,上海 200040
2. 感染性疾病及肿瘤基因诊断技术国家地方联合工程研究中心,湖南长沙 410000
3. 北京大学第一医院输血科,北京 100034
4. 陕西省人民医院输血科,陕西西安 710068
5. 天津医科大学总医院输血科,天津 300052
6. 中国医学科学院肿瘤医院输血科,北京 100020
7. 四川大学华西医院输血科,四川成都 610041
8. 北京医院输血科,国家老年医学中心,中国医学科学院老年医学研究院,北京 100730
9. 中南大学湘雅三医院输血科,湖南长沙 410017
10. 哈尔滨医科大学附属第一医院输血科,黑龙江哈尔滨 150007
11. 郑州大学第一附属医院输血科,河南郑州 450052
折叠

摘要

Abstract

Objective To investigate the infection status of HBV,HCV,and HIV in patients with secondary immunodeficiencyby a multicenter analysis.Methods Blood samples of preoperative or pre-transfusional patients were collected from ten medical institutions for HBV,HCV and HIV detection from July 2021 to December 2021 and from January 2023 to June 2023.Results A total of 25 927 samples were collected in this study,including 4 609(17.78%)from patients with secondary immunodeficiency,comprising 19 patients on hemodialysis,44 patients undergone organ transplantation,and 4 546 patients with malignant tumors.During the same period,21 318 general patients(82.22%)were also tested.Thepositive rates of HBV,HCV and HIV in secondary immunodeficiency patients were 7.29%,0.28%and 0.09%respectively,while thepositive rates of HBV,HCV and HIV were 5.40%,0.32%and 0.05%in general patientsrespectively.Moreover,there was significant difference in the positive detection rate of HBV assessed by the two methods.Among patients with secondary immunodeficiency,the detection rate of serological negativity and nucleic acid positivity was 1.04%(48 cases),whilethe detection rate of serological positivity and nucleic acid negativity was 0.52%(24 cases).Among general patients,the detection rate of serological negativity and nucleic acid positivity was 0.82%(174 cases),andthe detection rate of serological positivity and nucleic acid negativity was 0.42%(89 cases).Conclusion The risk of HBV infection insecondary immunodeficiency patients was higher than that general patients.Nucleic acid test has the advantage on increasing the detection rate of HBV in immunodeficient patients before surgery and blood transfusion.

关键词

免疫功能低下/核酸检测/传染病筛查/乙型肝炎病毒/丙型肝炎病毒/人类免疫缺陷病毒

Key words

Secondary immunodeficiency/Nucleic acid test/Infectious disease screenings/Hepatitis B virus/Hepatitis C virus/Human immunodeficiency virus

分类

医药卫生

引用本文复制引用

张琦,马兴焕,王鹏,杨江存,杜春红,李喜莹,秦莉,宫济武,夏荣,桂嵘,刘娟,张俊,周璐洁,刘凤华,吕先萍,胡俊华,周俊..继发性免疫功能低下患者HBV、HCV、HIV感染筛查情况分析[J].临床输血与检验,2025,27(4):478-483,6.

基金项目

本课题受国家自然科学基金面上项目(No.82070197、No.82370232)资助（No.82070197、No.82370232）

临床输血与检验

ISSN：1671-2587

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