肿瘤预防与治疗2025，Vol.38Issue(8)：680-687,8.DOI:10.3969/j.issn.1674-0904.2025.08.003
头颈部黏膜黑色素瘤临床特征及预后影响因素分析
Clinical Features and Prognostic Factors of Head and Neck Mucosal Mela-noma
摘要
Abstract
Objective:To investigate the clinical features and prognostic factors of head and neck mucosal melanoma(HNMM).Methods:A retrospective analysis was performed on the clinical data of 44 patients with HNMM admitted to and treated at Sichuan Cancer Hospital between 2014 and 2023,to evaluate their clinical characteristics and prognostic factors.Survival curves were generated with the Kaplan-Meier method;univariate analysis was conducted by the Log-rank test,and multivariable analysis was performed using the Cox proportional hazards regression model.Results:A total of 44 patients met the inclusion criteria.The median age of the co-hort was 60 years,with a male-to-female ratio of 1.1∶1.The primary tumor sites included the nasal cavity and paranasal sinuses(n=36,81.8%),oral cavity(n=5,11.4%),and other locations(n=3,6.8%).With a median follow-up of 10 months,the median overall survival(OS)was 11.58 months.The 1-,3-,and 5-year cumulative OS rates were 44.6%,22.0%,and 12.2%,respectively.No significant differ-ences in OS were observed based on age at diagnosis,primary tumor site,AJCC stage,surgical approach,need for reopera-tion,radiotherapy,chemotherapy,targeted therapy,presence of distant metastasis at diagnosis,or postoperative lymph node metastasis(all P>0.05).Immunotherapy was a factor affecting prognosis of HNMM patients(HR=0.320,95%CI:0.10～1.00;P=0.020).Conclusion:HNMM is an aggressive malignancy with a dismal prognosis.However,surgical re-section combined with immunotherapy may improve survival outcomes.关键词
头颈部肿瘤/黏膜黑色素瘤/预后/生存分析Key words
Head and neck tumor/Mucosal melanoma/Prognosis/Survival analysis分类
医药卫生引用本文复制引用
王春语,毛萌洁,葛俊,鲁迎春,柳斌..头颈部黏膜黑色素瘤临床特征及预后影响因素分析[J].肿瘤预防与治疗,2025,38(8):680-687,8.基金项目
This study was supported by grants from Wu Jieping Medical Foundation(No.320.6750). 吴阶平医学基金(编号:320.6750) （No.320.6750）
