肿瘤预防与治疗2025，Vol.38Issue(8)：712-718,7.DOI:10.3969/j.issn.1674-0904.2025.08.007
早期食管癌及癌前病变患者内镜黏膜下剥离术后中重度疼痛的发生率及影响因素:一项单中心观察性研究
Incidence and Influencing Factors of Moderate-to-Severe Pain Following Endoscopic Submucosal Dissection in Early Esophageal Cancer and Pre-cancerous Lesions:A Single-Center Observational Study
摘要
Abstract
Objective:To investigate the incidence and influencing factors of moderate-to-severe pain following endoscop-ic submucosal dissection(ESD)in patients with early esophageal cancer(EEC)and precancerous lesions,providing evi-dence for optimizing postoperative analgesia,enhancing recovery,and improving patient-reported satisfaction.Methods:The study consecutively enrolled 256 patients with EEC or precancerous lesions who underwent ESD at the De-partment of Gastroenterology,Yibin Second People's Hospital between January 2023 and December 2024.We collected patients'demographic characteristics,clinicopathologic data,and postoperative pain scores.Participants were divided into two groups according to whether moderate-to-severe pain occurred after surgery.Univariate analysis and multivariable logistic regression models were used to analyze factors influencing moder-ate-to-severe pain after ESD in patients with EEC and precancerous lesions.Results:The mean Numeric Rating Scale score among 256 patients was 2.74±1.55.Of these,69 patients were classified as having moderate-to-severe postoperative pain,yielding an incidence rate of 27.0%(69/256).Univariate and multivariable logistic regression analyses identified the fol-lowing independent risk factors for moderate-to-severe pain after ESD in patients with EEC or precancerous lesions:male sex(OR=2.565,95%CI:1.289～5.101,P=0.007),lesion longitudinal length≥5 cm(OR=2.345,95%CI:1.204～4.567,P=0.012),and submucosal invasion(OR=3.902,95%CI:1.305～11.674,P=0.015).Conclusion:Postopera-tive pain following ESD constitutes a significant clinical concern in managing EEC and precancerous lesions.The develop-ment of post-ESD pain is associated with multiple factors,including patient sex,lesion dimensions,and depth of invasion.Therefore,implementing individualized postoperative analgesia strategies based on these determinants is essential in clinical practice.关键词
早期食管癌/癌前病变/内镜黏膜下剥离术/疼痛/影响因素/Logistic回归模型Key words
Early esophageal cancer/Precancerous lesions/Endoscopic submucosal dissection/Pain/Influencing fac-tors/Logistic regression model分类
医药卫生引用本文复制引用
李倩,夏冬梅,黄萍,赵平,王洲丽,罗咏萍..早期食管癌及癌前病变患者内镜黏膜下剥离术后中重度疼痛的发生率及影响因素:一项单中心观察性研究[J].肿瘤预防与治疗,2025,38(8):712-718,7.基金项目
This study was supported by grants from National Expert Committee for Cancer Early Detection and Treat-ment Program(No.GTCZ-2023-5C-09). 中国消化道早癌医师共同成长计划科研项目(编号:GTCZ-2023-5C-09) （No.GTCZ-2023-5C-09）
