肿瘤预防与治疗2025，Vol.38Issue(8)：731-737,7.DOI:10.3969/j.issn.1674-0904.2025.08.010
细胞色素B561在肿瘤中的作用及研究进展
Roles and Recent Advances of Cytochrome B561 in Tumors
摘要
Abstract
Cytochrome B561(CYB561),a highly conserved transmembrane transporter protein with ferrireductase activi-ty,is ubiquitously expressed in humans.Recent studies have revealed its dual roles in malignant tumors,exemplified by pro-moting breast cancer(BC)progression while suppressing acute myeloid leukemia stem cell activity.CYB561 demonstrates significant prognostic value and represents a potential therapeutic target across malignancies.For instance,CYB561 knock-down suppresses breast cancer cell proliferation by inhibiting Akt/mTOR pathway and H2AFY-NF-κB signaling pathway.This article provides the systematic review of CYB561's pleiotropic functions in tumor biology,including iron metabolism and signaling pathway regulation,while evaluating its potentials as both a novel biomarker and a therapeutic target.We outline key priorities for translational research to inform novel approaches in precision oncology.关键词
细胞色素B561/CYB561/肿瘤/预后/生物标志物/靶向治疗Key words
Cytochrome B561/CYB561/Tumor/Prognosis/Biomarkers/Targeted treatment分类
医药卫生引用本文复制引用
廖鸿元,雷浩,李秀德,李雪玥,周晓峰..细胞色素B561在肿瘤中的作用及研究进展[J].肿瘤预防与治疗,2025,38(8):731-737,7.基金项目
This study was supported by grants from Science and Technology Department of Qinghai Province(No.2024-SF-L01). 青海省科技厅项目(编号:2024-SF-L01) （No.2024-SF-L01）
