生物技术通报2025，Vol.41Issue(8)：34-41,8.DOI:10.13560/j.cnki.biotech.bull.1985.2024-1083
基因编辑技术在牛种中的应用及研究进展
Application and Research Progress of Gene Editing Technology in Bovine
摘要
Abstract
Gene editing refers to the process of modifying specific targets in an organism's genome through gene editing techniques,achieving efficient and precise gene knockout,insertion,replacement,and other processes.Modern gene editing techniques include zinc finger nucleases(ZFNs),transcription activator like effector nucleases(TALENs),clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9(CRISPR/Cas9),and self-cleaving gene targeting technology in combination with programmable nucleases(SEGCPN).This paper reviews the breakthrough research progress of gene-edited cattle,including the famous gene-edited hornless cattle Buri,Spotigy and the US Food and Drug Administration(FDA)safety certified PRLR-SLICK,and summarizes the application of gene-edited cow in production,medicine and environment.The aim is to summarize the current application and research progress of gene editing technology in domestic cattle,in order to accelerate the industrialization process of gene editing technology in China and expand the application range of gene editing cattle.关键词
基因编辑牛/ZFNs/TALENs/CRISPR/Cas9/SEGCPNKey words
gene-edited cattle/ZFNs/TALENs/CRISPR/Cas9/SEGCPN引用本文复制引用
余永霞,杜再慧,朱龙佼,许文涛..基因编辑技术在牛种中的应用及研究进展[J].生物技术通报,2025,41(8):34-41,8.基金项目
农业生物育种国家科技重大专项(2022ZD04020),国家重点研发计划(2023YFF1001600) （2022ZD04020）
