生物技术通报2025，Vol.41Issue(8)：53-64,12.DOI:10.13560/j.cnki.biotech.bull.1985.2025-0088
莱茵衣藻响应重金属胁迫的分子防御机制研究进展
Research Progress in Molecular Defense Mechanisms of Chlamydomonas reinhardtii in Response to Heavy Metal Stress
摘要
Abstract
With the rapid development of urbanization and industrialization,heavy metal pollution has posed an immeasurable threat to aquatic ecosystems.Through the bioaccumulation effect in food chains,it severely endangers human health and has become a globally concerning environmental issue.In this context,green environmental remediation solutions represented by bioremediation have garnered significant attention due to their eco-friendliness and sustainability.As crucial primary producers in aquatic ecosystems,microalgae demonstrate high diversity and ecological adaptability,employing various molecular mechanisms to respond to heavy metal stress.Chlamydomonas reinhardtii,a unicellular eukaryotic microalga,maintains intracellular metal ion homeostasis through multi-layered physiological structures and regulatory mechanisms.Its unique capabilities in metal biotransformation and biosorption have established it as an important model organism for studying bioremediation of heavy metal-contaminated water bodies.The deepening understanding of C.reinhardtii's metal homeostasis mechanisms and rapid advancements in modern biotechnology have provided theoretical foundations for elucidating its defense strategies against heavy metal stress,while offering scientific guidance for its application in water remediation.This review summarizes key components and regulatory mechanisms involved in its responses to heavy metal stress,spanning from cell surface adaptations(e.g.,cell walls and extracellular polymeric substances)to intracellular processes(e.g.,metal transport proteins,heavy metal-binding factors,and metal-regulating organelles).Furthermore,it explores the potential applications of modern molecular biology techniques in enhancing C.reinhardtii's bioremediation capabilities and discusses its prospects in aquatic environmental protection.关键词
莱茵衣藻/重金属胁迫/细胞外聚合物/金属转运蛋白/金属结合因子Key words
Chlamydomonas reinhardtii/heavy metal stress/extracellular polymeric substances/metal transporters/metal-binding factors引用本文复制引用
李亚,蒋林,徐闯,王苏慧,马曌,王亮..莱茵衣藻响应重金属胁迫的分子防御机制研究进展[J].生物技术通报,2025,41(8):53-64,12.基金项目
江苏省基础研究计划资助项目(BK20231351),徐州市重点研发计划(社会发展)项目(KC23300),江苏高校优势学科建设工程资助项目(PAPD) （BK20231351）
