新医学2025，Vol.56Issue(8)：739-747,9.DOI:10.12464/j.issn.0253-9802.2025-0116
短期观察下间歇性置管注食对鼻咽癌放疗后吞咽障碍患者生存质量影响的研究
A short-term observational study on the impact of intermittent nasogastric feeding tube placement on quality of life in nasopharyngeal carcinoma patients with post-radiotherapy dysphagia
摘要
Abstract
Objective To explore the impact of intermittent nasogastric tube feeding on the quality of life of patients with dysphagia after radiotherapy for nasopharyngeal carcinoma in the short term.Methods Patients with dysphagia after radiotherapy for nasopharyngeal carcinoma who visited the Department of Rehabilitation Medicine of the Third Affiliated Hospital of Sun Yat-sen University from July 2022 to May 2025 were selected.At the time of visit,they were fed through a continuously indwelling nasogastric tube and were evaluated as suitable for intermittent nasogastric tube feeding.Three time points were selected for assessment:before the nasogastric tube was removed(T0),the third day after intermittent nasogastric tube feeding(T1),and the seventh day after intermittent nasogastric tube feeding(T2).The Functional Oral Intake Scale(FOIS)was used to assess the severity of dysphagia,and the Chinese version of the Swallowing Quality of Life Scale(SWAL-QOL)was used for questionnaire survey and scoring.Changes in the quality of life related to swallowing at the three assessment time points were observed,and stratified analysis was conducted based on age,gender,and severity of dysphagia to compare the differences and changes in the quality of life of patients with different individual characteristics.Results There was no statistically significant difference in FOIS grades among the three assessment time points(P>0.05).In terms of the quality of life related to swallowing,there were statistically significant differences in the scores of the four dimensions of psychological burden,swallowing symptoms,social interaction,and fatigue and sleep(all P<0.05).Further pairwise comparisons showed that in the dimensions of psychological burden,social interaction,and fatigue and sleep,the differences in scores between T0 and T1,and between T0 and T2 were statistically significant(all P<0.016 7);in the dimension of swallowing symptoms,the differences in scores between T0 and T1,between T0 and T2,and between T1 and T2 were all statistically significant(all P<0.016 7).There were no statistically significant differences in the scores of the five dimensions of eating time,food choice,language communication,fear of eating,and mental health among the three assessment time points.Further subgroup analyses were conducted based on age,gender,and FOIS grades.The results showed that there was no statistically significant interaction effect between subgroup and time in the scores of each dimension(P>0.05);in the four dimensions of psychological burden,swallowing symptoms,social interaction,and fatigue and sleep,the time effect was statistically significant(P<0.001),and the scores increased over time.In the gender subgroup analysis,the scores in the dimensions of swallowing symptoms and mental health were significantly different between the groups(P=0.035,0.011),with higher scores in the male group than in the female group;in the subgroup analyses based on age and FOIS grades,there was no statistically significant group effect(P>0.05).Conclusion Short-term observation shows that there are differences in the quality of life among patients with dysphagia after radiotherapy for nasopharyngeal carcinoma under the two feeding methods,and intermittent nasogastric tube feeding can improve the quality of life of patients.关键词
吞咽障碍/生存质量/持续性留置鼻胃管/间歇性置管Key words
Dysphagia/Quality of life/Persistent nasogastric tube placement/Intermittent tube placement引用本文复制引用
武惠香,周海彤,陈华玉,谢纯青,窦祖林,丘卫红..短期观察下间歇性置管注食对鼻咽癌放疗后吞咽障碍患者生存质量影响的研究[J].新医学,2025,56(8):739-747,9.基金项目
国家重点研发计划(2020YFC2004201) （2020YFC2004201）
广东省重点建设学科科研能力提升项目(自然科学类)(2024ZDJS128) （自然科学类）
