新医学2025，Vol.56Issue(8)：794-807,14.DOI:10.12464/j.issn.0253-9802.2024-0476
基于从肝论治的中药方剂联合抗甲状腺药物治疗甲状腺功能亢进症疗效分析
Efficacy of traditional Chinese medicine formulas based on liver regulation theory combined with anti-thyroid drugs for hyperthyroidism
摘要
Abstract
Objective To systematically evaluate the clinical efficacy of traditional Chinese medicine(TCM)based on liver regulation theory combined with anti-thyroid drugs in the treatment of hyperthyroidism,aiming to provide more sufficient evidence of evidence-based medicine for the application of TCM in hyperthyroidism.Methods Studies related to TCM treatment of hyperthyroidism based on liver regulation theory were retrieved from CNKI,Wanfang Database,Chongqing VIP Database,Chinese Biomedical Literature Database,Web of Science,PubMed,Cochrane Library and Embase until November 30,2024.After screening the eligible studies,the quality of the studies was evaluated.Revman 5.4 software was used to systematically re-evaluate the efficacy.Results A total of 36 published studies were included,including 2 616 patients,1 309 in the control group and 1 307 in the study group.Comparison of thyroid function improvement between two groups showed that TSH elevation in the study group was higher than that in the control group(I 2=93%,SMD=1.16,95%CI(0.81,1.51),P<0.000 01),and decreased FT3(I 2=95%,SMD=-1.56,95%CI(-1.98,-1.14),P<0.000 01)and FT4(I 2=96%,SMD=-1.78,95%CI(-2.25,-1.30),P<0.000 01)were better than those in the control group.In addition,the symptoms were more significantly mitigated in the study group(I 2=93%,SMD=-1.55,95%CI(-1.95,1.15),P<0.000 01).The clinical response rate in the study group was higher than that in the control group(I 2=0%,RR=1.23,95%CI(1.19,1.27),P<0.000 01).Conclusion TCM based on liver regulation theory combined with anti-thyroid drugs can better improve thyroid function,relieve clinical symptoms and improve clinical efficacy,which remains to be validated by large-scale,high-quality clinical research.关键词
从肝论治/甲状腺功能亢进症/系统评价/抗甲状腺药物Key words
Liver regulation theory/Hyperthyroidism/Systematic evaluation/Anti-thyroid drugs引用本文复制引用
娄文凤,江润纬,刘群,周询,丁治国..基于从肝论治的中药方剂联合抗甲状腺药物治疗甲状腺功能亢进症疗效分析[J].新医学,2025,56(8):794-807,14.基金项目
陕西省中西医结合甲状腺病诊疗"双链融合"中青年科研创新团队(2022-SLRH-LG-005) （2022-SLRH-LG-005）
陕西省"秦创原"中医药创新研发转化项目(2022-QCYZH-043) （2022-QCYZH-043）
