中国临床医学2025，Vol.32Issue(4)：529-535,7.DOI:10.12025/j.issn.1008-6358.2025.20250397
免疫检查点抑制剂相关垂体炎的临床特征分析
Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitis
摘要
Abstract
Objective To analyze the clinical characteristics of immune checkpoint inhibitor(ICI)-related hypophysitis.Methods A retrospective analysis was conducted on patients diagnosed with ICI-related hypophysitis and treated at the Department of Endocrinology,The First Affiliated Hospital with Nanjing Medical University,between January 2020 and March 2025.Clinical manifestations and prognosis of patients were analyzed.Results Eleven patients with ICI-related hypophysitis were included.The average age was(62.27±7.63)years,and 9 patients(81.82%)were male.The median time to onset was 9.1 months,and the median number of treatment cycles received was 5.The primary initial symptoms were fatigue and anorexia.Hyponatremia was present in 3 patients(27.27%).Evaluation of anterior pituitary function revealed adrenocorticotropic hormone deficiency as the most common manifestation(90.91%,10/11),followed by hyperprolactinemia(81.82%,9/11).Posterior pituitary function remained normal in all patients.Pituitary magnetic resonance imaging showed no abnormality in 4 patients(44.44%).Thyroid dysfunction was observed in 6 patients(54.55%),one of whom(9.09%)also exhibited pancreatic endocrine dysfunction.The average follow-up duration was 36.5 months.Eight patients(72.73%)were alive at the last follow-up.None of the patients recovered their pituitary hormone function.Conclusions Endocrine adverse events induced by ICIs can involve multiple glandular systems.Clinicians should be highly vigilant for the possibility of ICI-induced hypophysitis in patients receiving ICIs who present with symptoms such as fatigue,anorexia,and hyponatremia.关键词
免疫检查点抑制剂/免疫相关不良反应/垂体炎/临床特征Key words
immune checkpoint inhibitor/immune-related adverse event/hypophysitis/clinical characteristic分类
医药卫生引用本文复制引用
王知笑,施云,孙敏,郑旭琴,杨涛,沈敏..免疫检查点抑制剂相关垂体炎的临床特征分析[J].中国临床医学,2025,32(4):529-535,7.基金项目
国家自然科学基金(82230028),南京医科大学第一附属医院青年科学基金培育计划(PY202415).Supported by the National Natural Science Foundation of China(82230028)and the Young Scholars Fostering Fund of The First Affiliated Hospital with Nanjing Medical University(PY202415). （82230028）
