中国临床医学2025，Vol.32Issue(4)：544-550,7.DOI:10.12025/j.issn.1008-6358.2025.20250550
程序性死亡受体1抑制剂导致甲状腺功能异常相关因素分析
Analysis of risk factors related to thyroid function abnormality caused by programmed death-1 inhibitors
摘要
Abstract
Objective To investigate the clinical characteristics and influencing factors of thyroid function abnormality(TFA)in patients with malignant tumors receiving programmed death-1(PD-1)inhibitor therapy,and its correlation with PD-1 inhibitors.Methods A retrospective analysis was conducted on the clinical data and biochemical indicators of 669 patients with malignant tumors who received PD-1 inhibitor therapy.Of these,561 patients maintained normal thyroid function(normal group),while 108 developed TFA(TFA group).Baseline characteristics,PD-1 inhibitor type,tumor type,and other indice were compared between the two groups.Univariate and multivariate logistic regression analyses were performed to identify related factors for TFA development.Additionally,the relationship between PD-1 inhibitors and TFA types was further analyzed within the TFA group.Results The rates of patients treated with pembrolizumab and with respiratory tumors were significantly higher in TFA group than those in the normal group(P＜0.01).Multivariate logistic regression analysis revealed that treatment with pembrolizumab and with respiratory tumor increased 5.350 and 1.514 times than tislelizumab and digestive tumor for risk of TFA development,respectively(P＜0.01).Within the TFA group,hypothyroidism was the predominant type(75,69.4%);treatment with pembrolizumab increased 2.999 times than tislelizumab for development risk of hyperthyroidism(P=0.042).Conclusions Among patients with malignant tumors treated with PD-1 inhibitors,pembrolizumab is more frequently associated with TFA,and patients with respiratory tumors were at a higher risk of developing TFA.Clinicians should closely monitor thyroid function in patients with respiratory tumors treated with pembrolizumab.关键词
程序性死亡受体1抑制剂/恶性肿瘤/甲状腺功能异常/免疫相关不良反应Key words
programmed death-1 inhibitor/malignant tumor/thyroid function abnormality/immune-related adverse event分类
医药卫生引用本文复制引用
汪丽红,宋汇洋,臧淑妃,叶玲,党雪菲..程序性死亡受体1抑制剂导致甲状腺功能异常相关因素分析[J].中国临床医学,2025,32(4):544-550,7.基金项目
上海市闵行区卫生健康系统优秀青年医技人才和药学人才培养项目(mwyjyx16).Supported by the Outstanding Young Medical Technical and Pharmaceutical Talents Development Program of the Healthcare System in Minhang District,Shanghai(mwyjyx16). （mwyjyx16）
