中国全科医学2025，Vol.28Issue(29)：3645-3652,8.DOI:10.12114/j.issn.1007-9572.2025.0087
血浆致动脉硬化指数与体检人群新发心力衰竭风险的队列研究
Cohort Study on the Association between the Atherogenic Index of Plasma and the Risk of Incident Heart Failure in a Physical Examination Population
摘要
Abstract
Background Heart failure(HF)is the end stage of a variety of cardiovascular diseases,high incidence,poor prognosis,seriously affect the quality of life of patients.The atherogenic index of plasma(AIP)is closely related to atherosclerosis,coronary heart disease and other cardiovascular diseases,and atherosclerosis is an important risk factor for heart failure.Objective To investigate the effect of the AIP index on the risk of new-onset HF.Methods This is a retrospective cohort study.99 755 active and retired employees of Kailuan Group who participated in the health examination of the 11 hospitals affiliated to Kailuan General Hospital from June 2006 to October 2007 were selected as the observation population,and the subjects were divided into 4 groups according to baseline AIP quartile,namely Group Q1:AIP<-0.56(n=24 937);Group Q2:-0.56≤AIP<-0.16(n=24 940);Group Q3:-0.16≤AIP<0.31(n=24 938);Group Q4:AIP≥0.31(n=24 940).Follow-up continued until 31 December 2021,during which the incidence of HF was recorded once a year.The incidence density of HF in the 4 groups was calculated.The cumulative incidence of HF in the 4 groups was calculated using the Kaplan-Meier method.The effect of AIP on the risk of new-onset HF was analysed by Cox regression.Results During a mean follow-up of 14.07(13.79,14.24)years,there were 3 337(3.35%)cases of new HF.There were 675,734,940 and 988 cases in group Q1-Q4,respectively,and the incidence density was 1.95/1 000,2.13/1 000,2.73/1 000 and 2.87/1 000 years,respectively.The cumulative incidence of new HF in the Q1-Q4 group was 2.47%,2.68%,3.48%and 3.63%,respectively.According to the Log-rank test,the differences were statistically significant(χ2=76.90,P<0.001).In multivariate Cox regression analysis,compared with Q1,the risk for new-onset HF in Q3 and Q4 was 1.16(95%CI=1.05-1.28)and 1.20(95%CI=1.08-1.33),respectively,and the differences were statistically significant(P<0.05).Conclusion AIP is an independent risk factor for new-onset HF,and the risk of new HF increases with the increase of AIP level.Early screening and evaluation of patients at high risk of HF can be achieved through AIP.关键词
心力衰竭/血浆致动脉硬化指数/危险因素/队列研究Key words
Heart failure/Atherogenic index of plasma/Risk factor/Cohort studies分类
医药卫生引用本文复制引用
邓洁,李康博,齐祺,吴欣雨,韩全乐,李雷,蒋越,郁静,吴若洁,吴寿岭..血浆致动脉硬化指数与体检人群新发心力衰竭风险的队列研究[J].中国全科医学,2025,28(29):3645-3652,8.基金项目
河北省医学课题重点研究计划项目(20231775) （20231775）
