中国全科医学2025，Vol.28Issue(29)：3668-3673,6.DOI:10.12114/j.issn.1007-9572.2024.0531
三酰甘油-葡萄糖指数纵向轨迹与老年人肝脏硬度状况的关联研究
Association of Longitudinal Trajectories of Triglyceride-glucose Index and Liver Stiffness Status in Elderly People
摘要
Abstract
Background The triglyceride-glucose(TyG)index is closely related to liver diseases.However,there is a lack of studies on the association between the longitudinal TyG index trajectories and liver stiffness in the elderly population,both at home and abroad.Objective This study aims to analyze the association between longitudinal trajectories of triglyceride-glucose index and liver stiffness status in elderly individuals.Methods The population was derived from the West China Elderly Preventive and Treatment Merging Cohort,comprising 2 736 individuals who participated in three or more health examinations between 2017 and 2022.Participants were aged≥60 years,had complete triacylglycerol and blood glucose measurements,and had no history of chronic liver disease at baseline.The group trajectory model(GBTM)was applied to establish the long-term longitudinal trajectories of the TyG index,and a binary Logistic regression model was used to analyze the association between the longitudinal trajectories of the TyG index and liver stiffness.Results Among the participants,376 individuals(13.7%)had elevated liver stiffness(LSM>7 kPa).The TyG longitudinal trajectories were divided into 5 groups,including 337 individuals(12.3%)in the low-stable group,1 172 individuals(42.8%)in the medium-low-stable group,921 individuals(33.7%)in the medium-stable group,268 individuals(9.8%)in the medium-high-increasing group,and 38 individuals(1.4%)in the highest-to-medium-high group.Logistic regression analysis showed that,after adjusting for confounding factors,compared to the low-stable group,the medium-low-stable group(OR=1.94,95%CI=1.13-3.43),medium-stable group(OR=3.04,95%CI=1.57-5.99),medium-high increasing group,and highest-to-medium-high group(OR=3.31,95%CI=1.02-10.36)had increased risk for elevated liver stiffness.Conclusion Elderly populations should be concerned about changes in the level of the TyG index,and when the TyG index is persistently high(≥8.78),liver health should be further examined.关键词
肝脏硬度/三酰甘油-葡萄糖指数/老年人/纵向轨迹/Logistic回归Key words
Liver Stiffness/Triglyceride-glucose index/Aged/Longitudinal trajectory/Logistic regression分类
医药卫生引用本文复制引用
刘小雪,廖加强,樊萌语,汪川,杨代兰,李佳圆,张本,吕良,冯琬婷,杨会芳,滕屹霖,马天佩,张韬,姜侠,龙璐..三酰甘油-葡萄糖指数纵向轨迹与老年人肝脏硬度状况的关联研究[J].中国全科医学,2025,28(29):3668-3673,6.基金项目
国家重点研发计划(2022YFC3600600) （2022YFC3600600）
四川省自然科学基金项目重点项目(2024NSFSC0050) （2024NSFSC0050）
