中国畜牧杂志2025，Vol.61Issue(8)：44-51,8.DOI:10.19556/j.0258-7033.20250422-04
铁死亡在雄性哺乳动物精子发生障碍及雄性不育中的作用研究进展
Research Progress on the Role of Ferroptosis in Spermatogenic Disorders and Male Infertility in Mammals
摘要
Abstract
Spermatogenesis is the core physiological process of male reproduction,and its dysfunction can lead to reduced animal fertility.Recent studies have found that ferroptosis,as a novel form of iron-dependent,lipid peroxidation-driven programmed cell death,has significant impact in male reproductive dysfunction and spermatogenic disorders.Ferroptosis can regulate the apoptosis of germ cell,the dysfunction of Sertoli cell,and the damage to the blood-testis barrier by modulating the activity of glutathione peroxidase 4(GPX4),iron metabolism disorders,and the accumulation of reactive oxygen species(ROS),thereby affecting the efficiency of spermatogenesis and sperm quality.This article systematically discusses the key molecular mechanisms and characteristics of ferroptosis,with a particular focus on its potential role in spermatogenic disorders and male infertility.It also summarizes intervention strategies targeting the ferroptosis pathway,providing a theoretical basis for a deeper understanding of the role of ferroptosis in male reproduction and to offer new insights and strategies for enhancing the reproductive performance of breeding males.关键词
铁死亡/精子发生/雄性不育/种公畜繁殖性能Key words
Ferroptosis/Spermatogenesis/Male infertility/Reproductive performance of breeding males分类
农业科技引用本文复制引用
李亚赛,张宇,陈大可,陈通,乔木,吴俊静,彭先文,梅书棋,冯越..铁死亡在雄性哺乳动物精子发生障碍及雄性不育中的作用研究进展[J].中国畜牧杂志,2025,61(8):44-51,8.基金项目
湖北省自然科学基金青年项目(2024AFC008) （2024AFC008）
湖北省农业科学院青年基金项目(2024NKYJJ15) （2024NKYJJ15）
湖北省重大科技项目(2023BAA029) （2023BAA029）
国家生猪产业技术体系项目(CARS-35) （CARS-35）
湖北省农业科技创新中心创新团队项目(2025-620-000-001-014) （2025-620-000-001-014）
