中国药业2025，Vol.34Issue(16)：100-103,4.DOI:10.3969/j.issn.1006-4931.2025.16.020
替奈普酶联合低分子肝素对ST段抬高型急性心肌梗死老年患者心肌损伤标志物及心功能的影响
Effect of Tenecteplase Combined with Low Molecular Weight Heparin on Myocardial Injury Markers and Cardiac Function in Elderly Patients with ST-Segment Elevation Acute Myocardial Infarction
摘要
Abstract
Objective To investigate the effects of tenecteplase combined with low molecular weight heparin on myocardial injury markers and cardiac function in elderly patients with ST-segment elevation acute myocardial infarction(STEMI).Methods A total of 102 elderly STEMI patients admitted to the Qinhuangdao Workers'Hospital from July 2018 to July 2023 were selected and divided into the control group(given urokinase combined with low molecular weight heparin)and the observation group(given tenecteplase combined with low molecular weight heparin)by the random number table method,with 51 cases in each group.Both groups were treated for 7 d.Results The total effective rate in the observation group was 92.16%,which was significantly higher than 70.59%in the control group(P<0.05).There was no statistically significant difference in myocardial perfusion grading between the two groups(P>0.05).After treatment,the creatine kinase,creatine kinase isoenzyme MB,cardiac troponin I,left ventricular end diastolic diameter,and left ventricular end systolic diameter in the two groups were significantly decreased,and the thrombin time,prothrombin time,activated partial thromboplastin time in the two groups were significantly prolonged,the left ventricular ejection fractions in the two groups were significantly increased,and the above indexes in the observation group were significantly better than those in the control group(P<0.05).The incidence of bleeding rate in observation group was significantly lower than that in the control group(P<0.05).The incidence of acute heart failure,malignant arrhythmia,shock,pulmonary edema,mortality rates were comparable between the two groups(P>0.05).Conclusion Tenecteplase combined with low molecular weight heparin in the treatment of elderly patients with STEMI has good efficacy,which can effectively improve the coagulation function,myocardial injury,and cardiac function.关键词
替奈普酶/低分子肝素/急性ST段抬高型心肌梗死/心肌损伤标志物/心功能/凝血功能Key words
tenecteplase/low molecular weight heparin/ST-segment elevation acute myocardial infarction/myocardial injury markers/cardiac function/blood coagulation function分类
医药卫生引用本文复制引用
王伟,董跃华,吴立梅,王晓凤,乔刚..替奈普酶联合低分子肝素对ST段抬高型急性心肌梗死老年患者心肌损伤标志物及心功能的影响[J].中国药业,2025,34(16):100-103,4.基金项目
河北省秦皇岛市科技局市级科学技术研究与发展计划自筹项目[202301A106]. （）
