转化医学杂志2025，Vol.14Issue(7)：13-17,5.DOI:10.3639/j.issn.2095-3097.2025.07.003
血清SAA/CRP比值与老年阿尔茨海默病住院患者肺部感染的关系
The Relationship between Serum SAA/CRP Ratio and Pulmonary Infection in Elderly Patients with Alzheimer's Disease Hospitalized
摘要
Abstract
Objective To explore the relationship between serum amyloid A/C-reactive protein(SAA/CRP)ratio and pulmonary infection in elderly hospitalized patients with Alzheimer's disease(AD).Methods A total of 120 elderly AD inpa-tients from the Fourth People's Hospital of Ya'an City from April 2023 to March 2025 were selected as the research subjects,including 38 patients with pulmonary infections during hospitalization(infection group)and 82 patients without pulmonary infections(non-infection group).Serum SAA and CRP levels were measured and the SAA/CRP ratio was calculated for both groups.Receiver operating characteristic(ROC)curve and the area under the curve(AUC)were used to analyze the assessment value of each index for pulmonary infection in elderly AD inpatients.Binary logistic stepwise regression analysis was employed to identify influencing factors for pulmonary infection in elderly AD inpatients.Results SAA,CRP levels,and the SAA/CRP ratio were higher in the infection group than in the non-infection group(P<0.05).The AUC(95%CI)for SAA,CRP,and the SAA/CRP ratio in evaluating pulmonary infection in elderly AD patients were 0.828(0.783-0.878),0.773(0.728-0.823),and 0.906(0.861-0.956),respectively.The AUC of the SAA/CRP ratio assessment was higher than that of SAA and CRP evaluation alone(Z=9.301,P<0.001;Z=12.257,P<0.001).The proportion of patients with age≥75 years,diabetes,smoking history,long-term immobilization,eating difficulties,and modified plaque index(mPLI)≥2 was higher in the infection group than in the non-infection group(P<0.05).Binary logistic stepwise regression analysis showed that long-term immobiliza-tion(OR=2.094,95%CI:1.088-4.029),diabetes(OR=2.192,95%CI:1.153-4.170),mPLI≥2(OR=2.270,95%CI:1.239-4.161),and SAA/CRP ratio(OR=3.714,95%CI:2.055-6.712)were independent influencing factors of pulmonary infection in elderly AD inpatients(P<0.05).Conclusion The elevated serum SAA/CRP ratio is closely associated with the risk of pul-monary infection in elderly hospitalized AD patients,and is expected to provide important evidence for clinical identification of high-risk populations and optimization of intervention strategies.关键词
阿尔茨海默病/老年人/肺部感染/淀粉样蛋白A/C反应蛋白/评估价值/影响因素Key words
Alzheimer's disease/Elderly/Pulmonary infection/Amyloid A/C-reactive protein/Evaluate value/Influ-encing factors分类
医药卫生引用本文复制引用
杨小燕,吴国林,涂尊魁,张莹,向敏,吴雅锋..血清SAA/CRP比值与老年阿尔茨海默病住院患者肺部感染的关系[J].转化医学杂志,2025,14(7):13-17,5.基金项目
四川省科技计划项目(2021YJ0166) （2021YJ0166）
四川省基层卫生事业发展研究中心科研项目(SWFZ24-Y-81) （SWFZ24-Y-81）
