转化医学杂志2025，Vol.14Issue(7)：41-46,6.DOI:10.3639/j.issn.2095-3097.2025.07.008
MRI联合血清IL-1β、IL-17对乳腺癌前哨淋巴结转移的预测价值
The Predictive Value of MRI Combined with Serum IL-1β and IL-17 for Sentinel Lymph Node Metastasis in Breast Cancer
摘要
Abstract
Objective To explore the predictive value of magnetic resonance imaging(MRI)combined with serum interleukin(IL)-1β and IL-17 for sentinel lymph node(SLN)metastasis in breast cancer.Methods We retrospectively selected 202 breast cancer patients admitted to Qingdao Central Hospital,University of Health and Rehabilitation Sciences from January 2022 to December 2024.The patients were divided into a metastasis group(53 cases)and a non-metastasis group(149 cases)based on the presence or absence of SLN metastasis.All patients underwent MRI examination upon admission,and the quantitative MRI parameters(long-to-short diameter ratio,signal enhancement ratio[SER],and apparent diffusion coefficient[ADC]value)were obtained.Serum IL-1β and IL-17 levels were detected using chemiluminescence immunoassay.Multivariate Logistic stepwise regression analysis was used to identify influencing factors for SLN metastasis in breast cancer.The ROC curve and AUC were used to evaluate the predictive value of MRI quantitative parameters,serum IL-1β,and IL-17 individually and in combination for SLN metastasis in breast cancer.Results The long-to-short diameter ratio,SER,and serum IL-1β and IL-17 levels in the metastasis group were higher than those in the non-metastasis group,while the ADC value was lower[(1.39±0.16)vs(1.03±0.12),(86.93±10.58)%vs(64.91±8.44)%,(14.76±4.35)pg/mL vs(5.09±1.28)pg/mL,(269.71±23.94)pg/mL vs(247.15±19.46)pg/mL,(0.81±0.17)×10-3 mm2/s vs(0.94±0.15)×10-3 mm2/s,P<0.05].Multivariate Logistic stepwise regression analysis showed that vascular invasion,long-to-short diameter ratio≥1.21,SER≥75.92%,IL-1β≥9.93 pg/mL,and IL-17≥258.43 pg/mL were risk factors for SLN metastasis in breast cancer,while ADC>0.88×10-3 mm2/s was a protective factor(OR=2.394,95%CI:1.464-3.916,P=0.001;OR=2.678,95%CI:1.680-4.269,P<0.001;OR=3.360,95%CI:1.885-5.991,P<0.001;OR=2.751,95%CI:1.637-4.625,P<0.001;OR=3.171,95%CI:1.857-5.414,P<0.001;OR=0.259,95%CI:0.150-0.449,P<0.001).The AUC for the combined detection of MRI quantitative parameters(long-to-short diameter ratio,SER,ADC)and serum IL-1β and IL-17 in predicting SLN metastasis was significantly superior to individual predictions(Z=8.124,11.807,9.518,10.843,12.415,P<0.001).Conclusion The MRI quantitative parameters(long-to-short diameter ratio,SER,ADC)and serum IL-1β and IL-17 levels are all associated with SLN metastasis in breast cancer and can serve as important indicators for predicting SLN metastasis.Moreover,the combined detection of MRI quantitative parameters with serum IL-1β and IL-17 demonstrates superior predictive value.关键词
磁共振成像/白介素1β/白介素17/乳腺癌/前哨淋巴结转移/预测价值Key words
Magnetic resonance imaging/Interleukin-1β/Interleukin-17/Breast cancer/Sentinel lymph node metastasis/Predictive value分类
医药卫生引用本文复制引用
刘松岭,张雁,孙歆,谭政帅,高林,从红英..MRI联合血清IL-1β、IL-17对乳腺癌前哨淋巴结转移的预测价值[J].转化医学杂志,2025,14(7):41-46,6.基金项目
吴阶平医学基金会临床科研专项资助基金(320.6750.2023-18-108) （320.6750.2023-18-108）
