转化医学杂志2025，Vol.14Issue(7)：64-68,5.DOI:10.3639/j.issn.2095-3097.2025.07.012
宫颈癌组织中SHC1、SOS1表达水平与患者病理特征、预后的关系
The Correlation between the SHC1,SOS1 in Cervical Cancer Tissues and Pathological Characteristics and Prognosis of Patients
摘要
Abstract
Objective To explore the relationship between the expression levels of Src homology 2 domain-containing adaptor protein 1(SHC1)and Son of sevenless homolog 1(SOS1)in cervical cancer tissues and the pathological characteristics and prognosis of patients.Methods A total of 106 patients with cervical cancer who underwent surgery at Shizhong District Maternal and Child Health Hospital from March 2016 to March 2022 were selected.The expression levels of SHC1 and SOS1 in cancer tissues and adjacent tissues were detected by immunohistochemistry.Differences in SHC1 and SOS1 expression among patients with different pathological characteristics were compared.Patients were followed up for 3 years postoperatively,and prognosis differences among those with different SHC1/SOS1 expression levels were compared.Multivariate Cox regression analysis was used to identify factors influencing prognosis.Results The positive rates of SHC1 and SOS1 in cervical cancer tissues(74.53%and 80.19%)were higher than those in adjacent tissues(33.02%and 35.85%)(P<0.05).Significant differences in SHC1 and SOS1 expression were observed among patients with different differentiation degrees,FIGO stages,and lymph node metastasis status(P<0.05).The 3-year overall survival rates of SHC1-positive and SOS1-positive patients were 46.84%and 49.41%,respectively,lower than those of SHC1-negative(88.89%)and SOS1-negative patients(90.48%)(P<0.05).Multivariate analysis showed that poor tumor differentiation(HR=1.917,95%CI:1.263-2.911),SHC1 positivity(HR=2.765,95%CI:1.645-4.648),SOS1 positivity(HR=3.133,95%CI:1.806-5.434),and lymph node metastasis(HR=2.246,95%CI:1.411-3.573)were independent risk factors for prognosis(P<0.05).Conclusion SHC1 and SOS1 are highly expressed in cervical cancer tissues.Their expression levels correlate with FIGO stage,tumor differentiation degree,and lymph node metastasis,serving as independent risk factors for prognosis.关键词
宫颈癌/含有Src同源2结构域的衔接蛋白1/七激酶子同源物1/病理特征/预后Key words
Cervical cancer/Src homology 2 domain-containing adaptor protein 1/Son of sevenless homolog 1/Pathological characteristics/Prognosis分类
医药卫生引用本文复制引用
罗丽琴,王亚桃,邓燕斌,郑丽萍,宋锐,周敏..宫颈癌组织中SHC1、SOS1表达水平与患者病理特征、预后的关系[J].转化医学杂志,2025,14(7):64-68,5.基金项目
四川省科技计划项目(2022YFS0085) （2022YFS0085）
