转化医学杂志2025，Vol.14Issue(7)：69-73,5.DOI:10.3639/j.issn.2095-3097.2025.07.013
血清KLK6、α-syn预测缺血性脑卒中后认知功能障碍的临床价值
Clinical Value of Serum KLK6 and α-syn in Predicting Cognitive Dysfunction after Ischemic Stroke
摘要
Abstract
Objective To explore the clinical value of serum kallikrein 6(KLK6)and α-synuclein(α-syn)in predicting cognitive dysfunction after ischemic stroke(iPSCI).Methods A retrospective selection was made of 196 patients with ischemic stroke admitted to the First People's Hospital of Xianyang from January 2020 to June 2024,among whom 72 cases developed iPSCI(cognitive impairment group)and 124 cases had normal cognitive function(cognitive normal group).The levels of serum KLK6 and α-syn and baseline data at admission of the two groups at admission were compared.The receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of serum KLK6,α-syn and their combination for iPSCI.The influencing factors of iPSCI were explored by multivariate Logistic stepwise regression analysis.Results The levels of serum KLK6 and α-syn in the cognitive impairment group were higher than those in the cognitive normal group(P<0.05).The AUC(95%CI)of serum KLK6,α-syn and their combination for predicting iPSCI were 0.843(0.793-0.893),0.716(0.671-0.766),and 0.922(0.877-0.972),respectively.Multivariate analysis showed that smoking history(OR=2.042,95%CI:1.117-3.735),hypertension(OR=2.354,95%CI:1.190-4.656),NIHSS score at admission(OR=2.841,95%CI:1.384-5.832),serum KLK6 level(OR=3.777,95%CI:1.963-7.269),and serum α-syn level(OR=3.111,95%CI:1.840-5.261)were independent risk factors for iPSCI(P<0.05).Conclusion The levels of serum KLK6 and α-syn at admission are significantly correlated with the occurrence of iPSCI.The combined detection of the two has a high predictive value and can be used as potential biomarkers for the early identification of high-risk patients with iPSCI.关键词
缺血性脑卒中/认知功能障碍/激肽释放酶6/α-突触核蛋白/临床价值/影响因素Key words
Ischemic stroke/Cognitive dysfunction/Kallikrein 6/α-synuclein/Clinical value/Influencing factors分类
医药卫生引用本文复制引用
吴雅欣,鱼丽萍,孔维,陈鹏,潘欢,赵锦华..血清KLK6、α-syn预测缺血性脑卒中后认知功能障碍的临床价值[J].转化医学杂志,2025,14(7):69-73,5.基金项目
陕西省自然科学基础研究计划项目(2020JQ-928) （2020JQ-928）
