转化医学杂志2025，Vol.14Issue(7)：111-116,6.DOI:10.3639/j.issn.2095-3097.2025.07.021
妊娠期高血压疾病患者血清PECAM-1、NO水平及临床意义
Analysis of Serum Platelet Endothelial Cell Adhesion Molecule-1 and Nitric Oxide Expression Levels and Their Clinical Significance in Patients with Gestational Hypertension
摘要
Abstract
Objective To investigate the levels and clinical significance of serum platelet endothelial cell adhesion mol-ecule-1(PECAM-1)and nitric oxide(NO)in patients with hypertensive disorder complicating pregnancy(HDCP).Methods A total of 120 HDCP patients admitted to Hebei North University Affiliated Second Hospital from June 2022 to June 2024 were selected as the study group(including 70 cases of gestational hypertension,34 cases of mild preeclampsia,and 16 cases of severe preeclampsia),with 120 healthy pregnant women undergoing prenatal examination during the same period as the control group.Serum PECAM-1 and NO levels were compared between the study group and the control group,as well as among different types of HDCP patients.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic value of serum PE-CAM-1 and NO levels for HDCP.Patients in the study group were followed until delivery and divided into good outcome group(n=98)and poor outcome group(n=22)based on delivery outcomes.Basic data and serum PECAM-1,NO levels were compared between these two groups,and logistic regression analysis was used to identify influencing factors for poor delivery outcomes.Results Serum PECAM-1 and NO levels in the study group were lower than those in the control group(P<0.05).Significant dif-ferences existed in these levels among HDCP subtypes(P<0.05),with the order:gestational hypertension>mild preeclampsia>severe preeclampsia.ROC analysis showed that the areas under the curve(AUC)for diagnosing HDCP were 0.852 for PECAM-1 and 0.819 for NO;the combined AUC was 0.939.The diagnostic value of the combination was significantly higher than that of individual indicators(P<0.05).Statistically significant differences(P<0.05)were observed between the good and poor outcome groups in disease severity,24-hour urinary protein quantification,systolic blood pressure,diastolic blood pressure,age,body mass index(BMI),and serum PECAM-1,NO levels.Logistic regression analysis confirmed that disease severity,24-hour uri-nary protein quantification,systolic blood pressure,age,PECAM-1,and NO levels were influencing factors for poor delivery outcomes in HDCP patients(P<0.05).Conclusion Serum PECAM-1 and NO levels are decreased in HDCP patients com-pared to healthy pregnant women.Their combination demonstrates high diagnostic efficiency for HDCP and correlates with poor delivery outcomes.关键词
妊娠高血压/血小板内皮细胞黏附分子-1/一氧化氮/诊断Key words
Hypertensive disorder complicating pregnancy/PECAM-1/NO/Diagnosis分类
医药卫生引用本文复制引用
田秀娟,苏心镜,杨恩亮,全慧,祁广晶,任熙,李聪颖,武莉芳,闫利荣,陈云飞..妊娠期高血压疾病患者血清PECAM-1、NO水平及临床意义[J].转化医学杂志,2025,14(7):111-116,6.基金项目
河北省医学科学研究课题计划项目(20210125) （20210125）
