转化医学杂志2025，Vol.14Issue(7)：160-164,5.DOI:10.3639/j.issn.2095-3097.2025.07.031
羟苯磺酸钙联合骨化三醇对糖尿病肾病患者氧化应激、微炎症状态及冠状动脉钙化的影响
Effects of Calcium Dobesilate Combined with Calcitriol on Oxidative Stress,Microinflammatory Status and Coronary Artery Calcification in Diabetic Nephropathy Patients
摘要
Abstract
Objective To observe the effect of calcium dobesilate combined with calcitriol on oxidative stress,mi-croinflammatory status,and coronary artery calcification in diabetic nephropathy(DN)patients.Methods Fifty patients with DN admitted to the First Affiliated Hospital of Xinjiang Medical University from May 2023 to March 2024 were selected.Using the sealed envelope randomization method,the subjects were randomly assigned to the monotherapy group(calcitriol alone,25 cases)and the combined therapy group(calcium dobesilate combined with calcitriol,25 cases).Comparison be-tween the two groups was made on renal function[blood urea nitrogen(BUN)and serum creatinine(Scr)],oxidative stress[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)],microinflammatory status[high-sensitivity C-reactive pro-tein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)],coronary artery calcium score(CACS),and adverse reactions.Results After treatment,the levels of BUN[(4.13±0.87)mmol/L],Scr[(71.84±7.51)μmol/L],hs-CRP[(5.92±1.01)mg/L],IL-6[(0.42±0.05)ng/L],TNF-α[(6.32±0.89)μg/L],and CACS[(64.28±4.97)points]in the combina-tion therapy group were significantly lower than those in the monotherapy group[(4.81±1.01)mmol/L,(79.26±8.25)μmol/L,(6.81±1.09)mg/L,(0.51±0.09)ng/L,(6.98±1.04)μg/L,and(72.31±5.23)points,respectively].The levels of SOD[(126.21±11.81)U/mL]and GSH-Px[(121.43±12.06)U/L]in the combination therapy group were higher than those in the monotherapy group[(107.65±10.72)U/mL and(112.59±11.48)U/L,respectively],and the differences were statistically sig-nificant(P<0.05).There was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined use of calcium dobesilate and calcitriol can significantly improve renal function,oxidative stress,and microinflammatory status in DN patients,while also delaying coronary artery calcification,with good safety.关键词
羟苯磺酸钙/骨化三醇/糖尿病肾病/氧化应激/微炎症状态/冠状动脉钙化Key words
Calcium dobesilate/Calcitriol/Diabetic nephropathy/Oxidative stress/Micro-inflamation status/Coronary artery calcification分类
医药卫生引用本文复制引用
阿尔帕提·阿不力提步,王顺,韩媛媛,穆福娜依·艾尔肯,冒智捷,康绍涛,刘鑫鹏..羟苯磺酸钙联合骨化三醇对糖尿病肾病患者氧化应激、微炎症状态及冠状动脉钙化的影响[J].转化医学杂志,2025,14(7):160-164,5.基金项目
新疆维吾尔自治区自然科学基金项目(2023D01C105) （2023D01C105）
2023年度"青年科研启航"专项基金项目(2023YFY-QKQN-18) （2023YFY-QKQN-18）
