中医临床研究2025，Vol.17Issue(11)：33-40,8.DOI:10.3969/j.issn.1674-7860.2025.11.006
表皮生长因子受体相关通路在气道黏液高分泌中的作用及中医药调控研究进展
A review on the role of epidermal growth factor receptor-related pathways in airway mucus hypersecretion and the traditional Chinese medicine regulation effect
摘要
Abstract
According to traditional Chinese medicine,airway mucus hypersecretion can be attributed to the category of"phlegm".When various pathogenic factors affect the Qi(气)transformation of Zang-fu organs(脏腑),the water and grain essence can not transform into blood,body fluid,which will combine and condense to form the pathological product"phlegm".Western medicine believes that airway mucus hypersecretion is a pathophysiological process in which various pathogenic factors cause excessive mucus production in airway mucosa.It will lead to the dysfunction of normal cilia clearance,weakened local defense function,repeated infection of pathogenic bacteria,and airway obstruction,thereby increasing the health risk of susceptible patients.Therefore,airway mucus hypersecretion is regarded as an important risk factor in the course of airway inflammatory disease.However,the clinical mechanism is not yet clear.Only by elucidating the potential mechanism and proposing safe and effective targeted therapeutic strategies can we guide clinical medication more effectively.The airway mucus hypersecretion is a complex pathological process,and various inflammatory cells,inflammatory mediators,and related cell signaling pathways can be involved in their regulation.A large number of studies have shown that the activation of epidermal growth factor receptor(EGFR)is an important signal to induce mucus metaplasia and upregulate mucin expression.EGFR related signaling pathway plays a key role in the formation and development of airway mucus hypersecretion.A variety of stimuli can lead to increased expression of EGFR in respiratory epithelial cells,causing high expression of mucin,leading to airway mucus hypersecretion.This article reviews the research on EGFR related pathway regulating airway mucus hypersecretion and the prevention and treatment of airway mucus hypersecretion by targeted regulation of EGFR related pathway in traditional Chinese medicine in recent years,in order to provide theoretical support for clinical practice.关键词
表皮生长因子受体通路/气道黏液高分泌/研究进展Key words
Epidermal growth factor receptor pathway/Airway mucus hypersecretion/Research progress分类
医药卫生引用本文复制引用
杨亚茹,张旭辉,李红梅,李世霞,周世欣,王丽丽,王文娟..表皮生长因子受体相关通路在气道黏液高分泌中的作用及中医药调控研究进展[J].中医临床研究,2025,17(11):33-40,8.基金项目
甘肃省科技重大专项项目(22ZD1FA001) （22ZD1FA001）
国家自然科学基金项目(82260889) （82260889）
甘肃省自然科学基金项目(24JRRD002). （24JRRD002）
