中医临床研究2025，Vol.17Issue(11)：78-84,7.DOI:10.3969/j.issn.1674-7860.2025.11.013
基于数据挖掘和网络药理学分析何泽云教授治疗肾病综合征的用药规律及核心药对作用机制
An analysis of the medication pattern of Professor HE Zeyun in the treatment of nephrotic syndrome and the action mechanism of core medicine pairs based on data mining and network pharmacology
摘要
Abstract
Objective:Through data mining and network pharmacology,the medication patterns of Professor HE Zeyun in the treatment of nephrotic syndrome and the action mechanism of core medicine pairs were explored in this study.Methods:The medical records of nephrotic syndrome patients admitted to the outpatient department of Professor HE Zeyun in the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from September 2018 to April 2024 were collected.Relevant data were sorted out by Excel and entered into the ancient and modern medical reports cloud platform V2.3.7 to analyze the age and gender of the patients,as well as the usage frequency,medicinal properties and tastes,and tropism meridian of Chinese medicines.The association rule analysis,clustering analysis,and complex network analysis of Chinese medicines included were performed to obtain core medicine pairs,so as to analyse their action mechanisms by network pharmacology.Results:A total of 680 TCM prescriptions were obtained,involving 174 Chinese medicines,and the total frequency was 28 520.Core medicines were Shanyao(Rhizoma Dioscoreae),Baimaogen(Rhizoma Imperatae),Sangye(Mulberry Leaf),Huangjing(Rhizoma Polygonati),and Maidong(Radix Ophiopogon).The medicinal properties were mainly cold and moderate properties,the medicinal taste was mainly sweet,and the tropism meridians were mainly lung meridian,spleen meridian,stomach meridian,and kidney meridian.The core medicine pair of Shanyao-Baimaogen was yielded by medicine association rule analysis,3 new prescription combinations were obtained by cluster analysis,and 1 core prescription was obtained by complex network analysis.The network pharmacological analysis showed that target genes such as EGFR,SRC,and TNF had high degree values,and Shanyao-Baimaogen could play a role in the treatment of nephrotic syndrome through signaling pathway in cancer,MAPK signaling pathway,and PI3K-Akt signaling pathway mainly.Conclusion:The core medicine pair used by Professor HE Zeyun in the treatment of nephrotic syndrome is Shanyao-Baimaogen.The action mechanism of the Shanyao-Baimaogen medicine pair in the treatment of nephrotic syndrome was closely related to the regulation of inflammatory response and immunity.关键词
肾病综合征/用药规律/数据挖掘/网络药理学Key words
Nephrotic syndrome/Medication pattern/Data mining/Network pharmacology分类
医药卫生引用本文复制引用
廖姗,邓紫薇,魏文璇,刘丙龙,彭亚军,何泽云..基于数据挖掘和网络药理学分析何泽云教授治疗肾病综合征的用药规律及核心药对作用机制[J].中医临床研究,2025,17(11):78-84,7.基金项目
湖南省自然科学基金(2023JJ30473) （2023JJ30473）
湖南省中医重点专科项目(czxm-sbk-2023001) （czxm-sbk-2023001）
湖南省卫生健康委卫生科研课题(W20243266). （W20243266）
