摘要
Abstract
Objective:To systematically evaluate the clinical efficacy of live dispersing prescriptions(疏肝类方)in the adjuvant treatment of chronic hepatitis B with depression by Meta-analysis.Methods:A systematic search in CNKI,CBM,VIP,Wanfang,PubMed and Cochrane Library was conducted to collect randomized controlled trials(RCTs)of live dispersing prescriptions in the adjuvant treatment of chronic hepatitis B with depression from the establishment of the database to March 18,2024.Chinese and English subject words and free words included"soothing the liver""regulating the liver""carefree""chronic viral hepatitis B""chronic hepatitis B""depression""Shugan""Xiaoyao""CHB",etc.Data was selected and extracted according to inclusion and exclusion criteria.Cochrane bias risk assessment tool was used to evaluate literature quality,and RevMan 5.4 software was used to carry out Meta-analysis.Results:A total of 14 articles were included,involving 1 234 patients.The results of Meta-analysis showed that:Compared with the control group,the adjuvant therapy with live dispersing prescriptions could significantly improve the clinical effective rate[OR=3.05,95%CI(2.11,4.41),P<0.000 01],reduce the Hamilton Depression Scale(HAMD)score[MD=-4.42,95%CI(-5.95,-2.88),P<0.000 01],and lower ALT value[MD=-23.66,95%CI(-31.95,-15.37),P<0.000 01].Conclusion:The efficacy of live dispersing prescriptions in the adjuvant treatment of chronic hepatitis B patients with depression are greatly improved,the HAMD score is significantly reduced,the liver function index is significantly ameliorated,and the quality of life of patients is greatly improved.Limited by the sample size and literature quality of the included studies,this study lacks observation of long-term clinical effects and continuous follow-up studies.Therefore,the above conclusion still needs to be verified by more high-quality studies.关键词
疏肝类方/慢性乙型肝炎/抑郁状态/Meta分析Key words
Live dispersing prescriptions/Chronic hepatitis B/Depression state/Meta-analysis分类
医药卫生
