中医临床研究2025，Vol.17Issue(13)：97-101,5.DOI:10.3969/j.issn.1674-7860.2025.13.017
基于"寒气生浊"论治特发性肺纤维化
Treating idiopathic pulmonary fibrosis based on the theory of"cold Qi tending to produce turbid and thick pathogens"
摘要
Abstract
Idiopathic pulmonary fibrosis(IPF)is a progressive fibrotic interstitial lung disease of unknown etiology,characterized by a high mortality rate and poor prognosis.Currently,modern medicine lacks specific treatment methods for IPF,making it one of the most difficult-to-treat lung diseases.In traditional Chinese medicine theory,this disease falls under the categories of Feibi(肺痹)and Feiwei(肺痿).The disease is in the lungs and is closely related to the spleen and kidneys.This disease is characterized by a deficiency in the root and a excess in the branch with clinical manifestations mainly including coughing up turbid saliva and foam-like saliva.The lung lobes are weakened and difficult to function,representing a chronic deficiency disease of the lungs.During the occurrence and development of the disease,the characteristic of pathogenic factors is the obstruction of meridians by phlegm and blood stasis.The theory of cold Qi(气)tending to produce turbid and thick pathogens originates from Huangdi Neijing(《黄帝内经》)and is closely related to the pathogenesis of phlegm and blood stasis obstructing meridians.This article explores the etiology and pathogenesis evolution of IPF based on the traditional Chinese medicine theory of"cold Qi tending to produce turbid and thick pathogens".Cold Qi is a pathogenic factor,and turbid pathogen is an important pathological product.The generation of turbid by cold Qi is an important link in the pathological process of IPF.Cold Qi can be either externally contracted or internally generated,both of which can lead to lung malnutrition,dysfunction of the internal organs,and further produce phlegm and blood stasis."Phlegm"originates from the kidney,is generated by the spleen,and is stored in the lungs.It turns into turbidity when exposed to cold Qi."Stasis"arises from impeded blood flow,either due to obstruction in the meridians or insufficient ability to circulate.When combined with"cold Qi",stasis produces turbidity."Phlegm or blood stasis"cannot solely harm the lungs.Due to the transformation of cold Qi into turbidity,the lung body loses its function,and the lung lobes fail to be nourished,ultimately leading to pulmonary fibrosis changes.Based on this theory,this article proposes therapeutic principles of warming Yang and dispelling cold,resolving phlegm and removing blood stasis,and nourishing the essence and strengthening the foundation.The aim is to ameliorate patients'clinical symptoms,delay the progression of the disease,and provide new ideas and methods for the treatment of IPF.关键词
肺病/肺痹/肺痿/特发性肺纤维化/《黄帝内经》Key words
Pulmonary disease/Lung impediment/Lung atrophy/Idiopathic pulmonary fibrosis/Huangdi Neijing分类
医药卫生引用本文复制引用
李畅,刘向阳,马君..基于"寒气生浊"论治特发性肺纤维化[J].中医临床研究,2025,17(13):97-101,5.基金项目
山东省中医药科技发展计划项目(2019-0127) （2019-0127）
陶凯全国名老中医药专家传承工作室项目(2014). （2014）
