中医临床研究2025，Vol.17Issue(14)：35-42,8.DOI:10.3969/j.issn.1674-7860.2025.14.005
从"体质可分论"看虚实体质的基因表达差异
Differences in gene expression of the deficiency and excess constitutions from the theory of TCM constitution differentiation
摘要
Abstract
Objective:To systematically explore the gene expression patterns of TCM deficiency constitution and excess constitution from a microscopic perspective,summarize their internal connections,so as to provide references for TCM constitution identification and regulation.Methods:Based on the theory of TCM constitution differentiation,according to the standards outlined in Classification and Determination of TCM Constitution(《中医体质分类与判定》),TCM constitutions can be categorized into deficiency constitutions,including Qi(气)deficiency type,Yang(阳)deficiency type,and Yin(阴)deficiency type,and excess constitutions,including phlegm-dampness type,blood stasis type,and damp-heat type.Literatures on constitutional gene expression were retrieved from the China National Knowledge Infrastructure(CNKI),Wanfang Data,and PubMed.We collected the differentially expressed genes of the six TCM constitution types and performed GO enrichment analysis by DAVID database,focusing on the molecular function and biological process,and then downloaded the results of enrichment analysis and organized them.Results:The gene expression patterns of the six TCM constitutions each had their own characteristics.Deficiency constitution was characterized by weakened immune function,decreased growth and development,abnormal body temperature regulation,and was susceptible to immune diseases,tumors,and infectious diseases.People with TCM excess constitution tended to have enhanced immune and inflammatory responses,as well as metabolic disorders such as lipid and protein abnormalities,making them more susceptible to glucose and lipid metabolism diseases or painful syndromes.Conclusion:This study shows that the gene expression patterns of TCM deficiency and excess constitutions each have their own characteristics and exhibit certain differences,which require further research for verification.关键词
中医体质/体质可分论/基因表达/富集分析/差异性Key words
TCM constitution/Constitution differentiation theory/Gene expression/Enrichment analysis/Difference分类
医药卫生引用本文复制引用
高志强,袁野..从"体质可分论"看虚实体质的基因表达差异[J].中医临床研究,2025,17(14):35-42,8.基金项目
四川中医药大健康产业发展与乡村振兴研究中心资助项目(DJKYB202204) （DJKYB202204）
四川省干部保健科研项目(川干研2022-503). （川干研2022-503）
