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Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration

Zhangrong Cheng Haiyang Gao Pengzhi Shi Anran Zhang Xianglong Chen Yuhang Chen Weikang Gan Kangcheng Zhao Shuai Li Cao Yang Yukun Zhang

Bone Research2025，Vol.13Issue(4)：P.1028-1046,19.

Bone Research2025，Vol.13Issue(4)：P.1028-1046,19.DOI:10.1038/s41413-025-00441-0

Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration

Zhangrong Cheng ¹Haiyang Gao ¹Pengzhi Shi ¹Anran Zhang ¹Xianglong Chen ¹Yuhang Chen ¹Weikang Gan ¹Kangcheng Zhao ¹Shuai Li ¹Cao Yang ¹Yukun Zhang¹

作者信息

1. Department of Orthopedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China
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摘要

关键词

lamp knockout/Intervertebral Disc Degeneration/Dyrk/Glutamine Metabolism/Senescence/Senescence Associated Secretory Phenotype/intervertebral disc degeneration idd/nucleus pulposus cells npc plays

分类

临床医学

引用本文复制引用

Zhangrong Cheng,Haiyang Gao,Pengzhi Shi,Anran Zhang,Xianglong Chen,Yuhang Chen,Weikang Gan,Kangcheng Zhao,Shuai Li,Cao Yang,Yukun Zhang..Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration[J].Bone Research,2025,13(4):P.1028-1046,19.

Bone Research

ISSN：2095-4700

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