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Age-and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging

Dilara Yilmaz Francisco C.Marques Lorena Gregorio Jérôme Schlatter Christian Gehre Thurgadevi Pararajasingam Wanwan Qiu Neashan Mathavan Xiao-Hua Qin Esther Wehrle Gisela A.Kuhn Ralph Müller

Bone Research2025,Vol.13Issue(4):P.957-967,11.
Bone Research2025,Vol.13Issue(4):P.957-967,11.DOI:10.1038/s41413-025-00428-x

Age-and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging

Dilara Yilmaz 1Francisco C.Marques 1Lorena Gregorio 1Jérôme Schlatter 1Christian Gehre 1Thurgadevi Pararajasingam 1Wanwan Qiu 1Neashan Mathavan 1Xiao-Hua Qin 1Esther Wehrle 2Gisela A.Kuhn 1Ralph Müller1

作者信息

  • 1. Institute for Biomechanics,ETH Zurich,Zurich,Switzerland
  • 2. Institute for Biomechanics,ETH Zurich,Zurich,Switzerland AO Research Institute Davos,Davos Platz,Switzerland
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摘要

关键词

molecular cellular mechanismsemerging/osteocyte lacuno canalicular network/bone remodeling/therapeutic targets/premature aging/polgd d mouse model/reduced bone density/age related osteoporosis

分类

临床医学

引用本文复制引用

Dilara Yilmaz,Francisco C.Marques,Lorena Gregorio,Jérôme Schlatter,Christian Gehre,Thurgadevi Pararajasingam,Wanwan Qiu,Neashan Mathavan,Xiao-Hua Qin,Esther Wehrle,Gisela A.Kuhn,Ralph Müller..Age-and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging[J].Bone Research,2025,13(4):P.957-967,11.

基金项目

the European Research Council(ERC Advanced MechAGE-ERC-2016-ADG-741883) (ERC Advanced MechAGE-ERC-2016-ADG-741883)

the Swiss National Science Foundation(no.188522). (no.188522)

Bone Research

2095-4700

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