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Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice

Pranay Ramteke Bahiyah Watson Mallory Toci Victoria A.Tran Shira Johnston Maria Tsingas Ruteja A.Barve Ramkrishna Mitra Richard F.Loeser John A.Collins Makarand V.Risbud

Bone Research2025，Vol.13Issue(4)：P.925-938,14.

Bone Research2025，Vol.13Issue(4)：P.925-938,14.DOI:10.1038/s41413-025-00422-3

Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice

Pranay Ramteke ¹Bahiyah Watson ¹Mallory Toci ¹Victoria A.Tran ¹Shira Johnston ¹Maria Tsingas ¹Ruteja A.Barve ²Ramkrishna Mitra ³Richard F.Loeser ⁴John A.Collins ¹Makarand V.Risbud¹

作者信息

1. Department of Orthopedic Surgery,Sidney Kimmel Medical College,Thomas Jefferson University,Philadelphia,PA 19107,USA
2. Department of Genetics,Genome Technology Access Centre at the McDonnell Genome Institute,Washington University,School of Medicine,St.Louis,MO 63110,USA
3. Department of Pharmacology and Biostatistics,Sidney Kimmel Cancer Center,Thomas Jefferson University,Philadelphia,PA,USA
4. Thurston Arthritis Research Center and the Division of Rheumatology,Allergy,and Immunology,University of North Carolina School of Medicine,3300 Thurston Building,Campus Box 7280,Chapel Hill,NC 27599-7280,USA
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摘要

关键词

intervertebral disc degeneration/skeletal tissue/autophagy/conditional del/intervertebral disc/sirt/disc degeneration/senescence

分类

临床医学

引用本文复制引用

Pranay Ramteke,Bahiyah Watson,Mallory Toci,Victoria A.Tran,Shira Johnston,Maria Tsingas,Ruteja A.Barve,Ramkrishna Mitra,Richard F.Loeser,John A.Collins,Makarand V.Risbud..Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice[J].Bone Research,2025,13(4):P.925-938,14.

基金项目

supported by the Michael Michelson Gift Fund and NIA grants R01AG073349(M.V.R.),R01AG044034(R.F.L.),and R01AG078609(J.C.). （M.V.R.）

Bone Research

ISSN：2095-4700

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