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SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis

Xiangyu Zu Shenghong Chen Zhengyuan Li Lin Hao Wenhan Fu Hui Zhang Zongsheng Yin Yin Wang Jun Wang

Bone Research2025，Vol.13Issue(4)：P.910-924,15.

Bone Research2025，Vol.13Issue(4)：P.910-924,15.DOI:10.1038/s41413-025-00421-4

SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis

Xiangyu Zu ¹Shenghong Chen ²Zhengyuan Li ²Lin Hao ²Wenhan Fu ²Hui Zhang ³Zongsheng Yin ³Yin Wang ⁴Jun Wang²

作者信息

1. Department of Oncology,The First Affiliated Hospital of Anhui Medical University,Anhui,China
2. Department of Orthopaedics,The First Affiliated Hospital of Anhui Medical University,Anhui,China Anhui Province Key Laboratory of zoonoses,Anhui Medical University,Hefei,China
3. Department of Orthopaedics,The First Affiliated Hospital of Anhui Medical University,Anhui,China
4. Department of Wound Repair&Plastic and Aesthetic Surgery,the First Affiliated Hospital of Anhui Medical University,Anhui,China Anhui Public Health Clinical Center,Anhui,China
折叠

摘要

关键词

osteoarthritis oa aberrant mechanical stress/SPI/PERK/Chondrocyte senescence/Mechanical stress/Osteoarthritis/chondrocyte senescence/Mitochondrial unfolded protein response

分类

临床医学

引用本文复制引用

Xiangyu Zu,Shenghong Chen,Zhengyuan Li,Lin Hao,Wenhan Fu,Hui Zhang,Zongsheng Yin,Yin Wang,Jun Wang..SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis[J].Bone Research,2025,13(4):P.910-924,15.

基金项目

supported by the Anhui Provincial Natural Science Foundation(Grant No.2308085MH250) （Grant No.2308085MH250）

the Natural Science Research Project of Anhui Educational Committee(Grant No.2023AH053327) （Grant No.2023AH053327）

the Scientific Research Fund Project of Anhui Medical University(2020xkj039). （2020xkj039）

Bone Research

ISSN：2095-4700

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