生物资源2025，Vol.47Issue(4)：317-323,7.DOI:10.14188/j.ajsh.20250617001
中性粒细胞调控肿瘤发生、发展与转移的研究进展
The roles of neutrophils in regulating tumorigenesis,development,and metastasis
摘要
Abstract
Neutrophils,as pivotal components of the innate immune system,have recently attracted growing atten-tion for their multifaceted roles within the tumor immune microenvironment.Emerging evidence demonstrated that neu-trophils are extensively infiltrated in various solid tumors,and their quantity and functional status are strongly associated with patient prognosis and immunotherapy response.During tumorigenesis and progression,on one hand,neutrophils con-tribute to tumor growth and metastasis via promoting inflammation,immune evasion,angiogenesis,and establishing pre-metastatic niches;on the other hand,certain neutrophil subsets also exhibit antitumor properties,indicating their remarkable functional heterogeneity.Despite these insights,the dynamic regulatory mechanisms governing neutrophil phenotypic plasticity and developmental trajectories within the tumor microenvironment remain incompletely understood.This re-view provides a comprehensive overview of the roles of neutrophils in tumor initiation,progression and metastasis,with emphases on their phenotypic and functional diversity,interaction with other immune cells,and emerging applications in tumor immunotherapy.By summarizing recent advances and highlighting unresolved challenges,this review aims to deepen our understanding of neutrophil-mediated tumor immunity and to highlight the development of potential innovative strategies for their therapeutic targeting and clinical intervention.关键词
中性粒细胞/肿瘤微环境/功能异质性/免疫逃逸/肿瘤发生与转移Key words
neutrophils/tumor microenvironment/functional heterogeneity/immune evasion/tumorigenesis and metastasis分类
医药卫生引用本文复制引用
钟波,唐震..中性粒细胞调控肿瘤发生、发展与转移的研究进展[J].生物资源,2025,47(4):317-323,7.基金项目
国家自然科学基金(82425027) （82425027）
