生物资源2025，Vol.47Issue(4)：324-329,6.DOI:10.14188/j.ajsh.20250507001
寨卡病毒感染TLR3基因敲除小鼠模型的构建
Construction of a TLR3 gene knockout mouse model infected with Zika virus
摘要
Abstract
Toll-like receptor 3(TLR3)plays a crucial role in the inflammatory responses and neural damage asso-ciated with Zika virus(ZIKV)infection.However,the development of ZIKV infection models utilizing TLR3 gene knockout mice has been relatively delayed,and their potential applications remain inadequately explored.Therefore,es-tablishing appropriate animal infection models is significantly important for elucidating the pathogenic mechanisms of ZIKV and for developing effective prevention and treatment strategies.In this study,we successfully established and vali-dated a TLR3 knockout(KO)mouse model.This model demonstrates excellent experimental applicability regarding sys-temic infection characteristics,histopathological damage patterns,and immune response features of ZIKV,thereby pro-viding a reliable platform for in-depth exploration of the molecular mechanisms underlying ZIKV pathogenesis and the de-velopment of antiviral drugs.关键词
寨卡病毒/Toll样受体3/小鼠模型Key words
Zika virus/Toll-like receptor 3(TLR3)/mouse model分类
医药卫生引用本文复制引用
蔡曾,鲜巧阳,苏珊,龙子文,张璋,汤宏斌..寨卡病毒感染TLR3基因敲除小鼠模型的构建[J].生物资源,2025,47(4):324-329,6.基金项目
国家重点研发计划(2021YFF0702002) （2021YFF0702002）
湖北省自然科学基金青年项目(2024AFB103) （2024AFB103）
