分析测试学报2025，Vol.44Issue(9)：1741-1753,13.DOI:10.12452/j.fxcsxb.250408266
光电离质谱技术及其在呼出气检测中的应用进展
Progress of Photoionization Mass Spectrometry and Its Application in Exhaled Breath Detection
摘要
Abstract
Volatile organic compounds(VOCs)in human exhaled breath serve as end products of di-verse metabolic pathways,offering critical insights into the body's physiological and pathological states.The development of rapid analytical methods for small-molecule VOCs holds significant scientific val-ue and promising potential for noninvasive disease diagnosis.Direct inlet mass spectrometry(DIMS),owing to its high sensitivity,rapid analysis,and exceptional versatility,has emerged as a key tech-nique for high-throughput characterization of complex samples.Vacuum ultraviolet photoionization(VUV-PI),a core ionization technology for DIMS,exhibits distinct advantages,including high mo-lecular ion yield,minimal fragmentation,and broad operational pressure compatibility(from high vacuum to ambient conditions).Its ability to efficiently ionize compounds across a wide polarity range—from nonpolar to strongly polar species—makes it a powerful and versatile tool for mass spec-trometric detection.This article systematically reviews advancements in photoionization mass spec-trometry(PI-MS),covering critical components such as ionization sources,ion optics,and mass analyzers.Furthermore,it highlights recent progress in PI-MS-based exhaled breath analysis for dis-ease screening and discusses future perspectives in this rapidly evolving field.关键词
飞行时间质谱/离子迁移谱/光电离/呼出气/挥发性有机物/疾病筛查Key words
time-of-flight mass spectrometry/ion mobility spectrometry/photoionization/ex-haled breath/volatile organic compounds/disease screening分类
化学化工引用本文复制引用
李庆运,蒋吉春,陈平,蒋丹丹,李海洋,花磊..光电离质谱技术及其在呼出气检测中的应用进展[J].分析测试学报,2025,44(9):1741-1753,13.基金项目
国家自然科学基金项目(22174142) （22174142）
辽宁省自然科学基金项目(2024-MSBA-54) （2024-MSBA-54）
大连市科技人才创新支持项目(2023RQ016,2024RY022) （2023RQ016,2024RY022）
