分析测试学报2025，Vol.44Issue(9)：1754-1763,10.DOI:10.12452/j.fxcsxb.25052704
单细胞水平汞在大脑组织中的赋存规律研究进展
Research Progress in the Distribution Patterns of Mercury in Brain Tissue at the Single-cell Level
摘要
Abstract
Mercury(Hg),as a global pollutant,can accumulates in brain tissues and induces irre-versible neurodegenerative damage,posing a severe threat to human health.Conventional studies predominantly focus on tissue-level Hg content and distribution,masking its cellular heterogeneity.Single-cell investigations into Hg distribution within brain tissues unveil cell-type-specific accumula-tion and metabolic variations,resolving heterogeneous cellular responses to Hg exposure.These ad-vances deepen the understanding of Hg's neurotoxic mechanisms and provide scientific foundations for precise assessment of neurotoxic risks and development of targeted intervention strategies.This re-view summarizes the characteristics of single-cell Hg distribution in brain tissues,and discusses key determinants including Hg speciation,exposure conditions,cellular phenotypes,functional states,and tissue microenvironment.We further summarize advancements in single-cell metal detection tech-nologies for Hg analysis and critically address current challenges and future directions in this emerg-ing field.关键词
汞/单细胞/大脑组织/单细胞金属检测技术Key words
Hg/single-cell/brain tissue/single-cell metal detection technology分类
化学化工引用本文复制引用
袁俊豪,刘念,刘丽红,郭华,李莹莹,何滨,胡立刚..单细胞水平汞在大脑组织中的赋存规律研究进展[J].分析测试学报,2025,44(9):1754-1763,10.基金项目
国家自然科学基金资助项目(22206033) （22206033）
