Abstract
Transcranial focused ultrasound(tFUS)is an emerging non-invasive neuromodulation technique,and employs high-ly focused acoustic waves for precise,reversible,and non-invasive modulation of specific brain regions.Characterized by high spa-tial resolution,deep penetration,and adjustability,tFUS shows great potential in the field of pain management.This consensus state-ment provides a comprehensive overview of the technical principles and clinical benefits of tFUS,the neuromodulatory effects of tFUs in sensory processing,its translational applications in pathological pain conditions,safety and management of adverse events,standardized operational procedures,and future research directions,with the aim of guiding future studies and clinical applications of tFUS.(1)Technical principles and clinical advantages of tFUS,including its fundamental working mechanisms,critical parame-ters,biophysical effects,and clinical benefits.(2)Neuromodulatory effects of tFUS in sensory processing,emphasizing the precise modulation of key brain areas,multi-tiered neural regulatory mechanisms,effects on sensory functions.(3)Translational applica-tions in pathological pain conditions,encompassing chronic neuropathic pain,acute pain,experimental pain models and migraine.(4)Safety and adverse event management,including comprehensive safety evaluations,common adverse reactions and their manage-ment strategies,responses to serious adverse events,long-term safety considerations,and safety in specific populations.(5)Stan-dardized operational procedures for tFUS treatment,encompassing assessment of indications and contraindications,pre-treatment evaluations,parameter selection and optimization,monitoring during treatment,and post-treatment follow-up management.(6)Fu-ture directions,including optimization of treatment protocols,enhancement of clinical accessibility,broadening of indication scopes,and assessments of long-term efficacy and safety.Currently,clinical research on tFUS in pain management is relatively limited.This consensus statement is grounded in existing literature and expert insights to offer guidance for applications and future research direc-tions.Despite the challenges,tFUS holds promise as a significant complementary approach in chronic pain management,providing new therapeutic options for patients with refractory pain.However,there is still a significant gap between current preliminary re-search findings and their broad clinical application.Only through rigorous scientific research and clinical validation tFUS can play a pivotal role in the future of precise pain medicine.关键词
慢性疼痛/经颅聚焦超声/神经调控/精准医学/专家共识Key words
chronic pain/transcranial focused ultrasound/neuromodulation/precision medicine/expert consensus
