康复学报2025，Vol.35Issue(4)：433-438,6.DOI:10.3724/SP.J.1329.2025.04014
皮层抑制功能与腰椎间盘突出症慢性疼痛的相关性研究
Correlation Analysis between Cortical Inhibition Function and Chronic Pain Associated with Lumbar Disc Herniation
摘要
Abstract
Objective To explore the correlation between cortical silent period(CSP)and chronic pain in patients with lumbar disc herniation(LDH),and to provide an objective,sensitive and accurate indicator for chronic pain assessment in clinical practice.Methods A total of 61 patients with LDH treated in the Shanghai Tongji Hospital from March to December 2023 were recruited and divided into mild pain group and moderate pain group according to the Numerical Rating Scale(NRS)scores,with 22 and 39 cases in each group,respectively.Cortical excitability parameters[resting motor threshold(rMT)and CSP]and surface electromyog-raphy(sEMG)signals,including time-domain indices[average EMG(AEMG),root mean square(RMS)and integrated EMG(iEMG)]and frequency-domain indices[mean power frequency(MPF)and median frequency(MF)]between the two groups were compared.Additionally,the correlations between CSP and sEMG parameters were analyzed.Results(1)rMT and CSP:compared with the mild pain group,the CSP on the herniated side in the moderate pain group was significantly lower,with a statistically signifi-cant difference(P<0.05),while there were no statistically significant differences in CSP on the non-herniated side and rMT on both sides between the two groups(P>0.05).(2)sEMG:compared with the same side in the mild pain group,the iEMG,AEMG and RMS values in the moderate pain group were significantly lower(P<0.05),while MPF and MF were significantly higher(P<0.05).(3)Correlation between CSP and sEMG:bilateral CSP was positively correlated with time-domain sEMG parameters(iEMG,AE-MG,RMS)(P<0.05).Conclusion Chronic pain of LDH patients is associated with altered cortical inhibition,and CSP is closely related to both the severity of chronic pain and muscle function,suggesting its potential as an objective electrophysiological marker for pain assessment in LDH patients.关键词
腰椎间盘突出症/疼痛/皮层静息期/皮层抑制性/电生理评估Key words
lumbar disc herniation/pain/cortical silent period/cortical inhibition/electrophysiological assessment引用本文复制引用
顾春雅,许东升..皮层抑制功能与腰椎间盘突出症慢性疼痛的相关性研究[J].康复学报,2025,35(4):433-438,6.基金项目
国家重点研发计划"主动健康和人口老龄化科技应对"重点专项(2023YFC3603705) （2023YFC3603705）
