基础医学与临床2025，Vol.45Issue(9)：1139-1143,5.DOI:10.16352/j.issn.1001-6325.2025.09.1139
老年肿瘤微环境对免疫检查点抑制剂治疗的影响
Impact of the aging tumor microenvironment on immune checkpoint inhibitors therapy
摘要
Abstract
The role of tumor microenvironment(TME)in tumor genesis and progression has attracted increasing attention.This review describes the effects of aging on the function of immune cells,extra cellular matrix,vascula-ture,cytokines,and metabolites in the tumor microenvironment,which may alter the host's response to immune checkpoint inhibitors(ICIs)and relies on the results of the most recent clinical studies to evaluate the safety of ICIs for elderly oncology patients and potential adverse effects.关键词
肿瘤微环境/细胞外基质/衰老/免疫检查点抑制剂Key words
tumor microenvironment/extracellular matrix/aging/immune checkpoint inhibitors分类
医药卫生引用本文复制引用
周慧聪,邵亚娟..老年肿瘤微环境对免疫检查点抑制剂治疗的影响[J].基础医学与临床,2025,45(9):1139-1143,5.基金项目
北京协和医院中央高水平医院临床研究专项(2022-PUMCH-B-049) （2022-PUMCH-B-049）
