海洋科学2025，Vol.49Issue(3)：15-26,12.DOI:10.11759/hykx20241113002
底栖有孔虫卷转虫(Ammonia spp.)对环境磷浓度变化的分子响应机制
Molecular response mechanisms of benthic foraminifera Ammonia spp.to changes in environmental phosphorus con-centrations
摘要
Abstract
Phosphorus is an essential element for all living organisms and a limiting factor in marine primary productivity.As a widely distributed class of single-celled eukaryotic protozoa,benthic foraminifera play a crucial ecological role in the storage,release,migration,and transformation of phosphorus within benthic environments.This study explores the molecular regulatory mechanisms of the representative foraminifera genus,Ammonia,under varying phosphate concentrations using transcriptome analysis.We performed a differential expression analysis of key metabolic pathways,including phosphonate and phosphinate metabolism,as well as signaling cascades like the PI3K-AKT signaling pathway.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were used to infer the phosphorus metabolism strategies utilized by Ammonia spp.When phosphate concentrations were relatively low,Ammonia spp.preferentially utilized phosphate ester remineralization to sustain their phos-phorus supply and enhance the synthesis of phosphonates as a phosphorus reserve.Additionally,low phosphate concentrations upregulated genes associated with the cell cycle and apoptosis signaling.This upregulation activated downstream targets through signal transduction cascades,promoting fatty acid oxidation and glycolysis for ATP production,inducing autophagy,and triggering apoptosis.Conversely,under high phosphate conditions,Ammonia spp.favorably and specifically degraded 2-aminoethylphosphonate,serving as a dual nitrogen and phosphorus nu-trient source,thus maintaining cellular homeostasis by modulating the cell cycle and limiting cell proliferation.This study provides new insights into the molecular mechanisms by which benthic foraminifera adapt to alterations in environmental phosphorus concentrations.关键词
有孔虫/磷酸盐/转录组/膦酸酯/信号传导Key words
foraminifera/phosphate levels/transcriptome/phosphonate/signal transduction分类
海洋科学引用本文复制引用
陈婧,甄毓,米铁柱..底栖有孔虫卷转虫(Ammonia spp.)对环境磷浓度变化的分子响应机制[J].海洋科学,2025,49(3):15-26,12.基金项目
国家自然科学基金项目(42130410) （42130410）
国家重点研发计划课题(2022YFC3105202)National Natural Science Foundation of China,No.42130410 （2022YFC3105202）
National Key Research and Development Program of China,No.2022YFC3105202 （）
