海洋科学2025，Vol.49Issue(3)：116-125,10.DOI:10.11759/hykx20241030002
Argopecten属海湾扇贝和紫扇贝的寿命调控机制
Regulatory mechanism of lifespan of bay scallops and peru-vian scallops of Argopecten
摘要
Abstract
Marine bivalves hold significant economic,ecological,and sustainable developmental value in global fisheries and aquaculture.American scholars have reported that marine bivalves are ideal models for analyzing the regulatory mechanisms of natural aging and longevity.Bay scallops(Argopecten irradians)(<14 months)and Pe-ruvian scallops(A.purpuratus)(7-10 a)are not completely reproductively isolated;however,the genetic variations in their genomes resulting from long-term adaptation to different environments have led to distinct lifespans,providing unique materials for investigating lifespan evolution mechanisms.The insulin/insulin-like growth factor signaling(IIS)pathway is a key pathway involved in various life processes,including growth,metabolism,repro-duction,and lifespan.It is the first aging regulatory signaling pathway discovered and widely validated.This study reviews the potential mechanisms influencing lifespan determination through the IIS pathway in the two species of Argopecten from genetic and environmental perspectives.Genetic variation results in differences in protease activ-ity and phosphorylation levels of core genes within the IIS pathway.Under environmental stress,variations in IIS pathway regulation,antioxidant and DNA repair responses,and metabolic regulation may contribute to the differ-ences in lifespan among Argopecten scallops.This review provides new insights into evaluating lifespan evolution mechanisms in marine bivalves,further enhancing the theoretical understanding of aging and longevity mechanisms.Additionally,it offers theoretical foundations and biological markers for breeding long-lived,larger scallops.关键词
Argopecten属扇贝/寿命/IIS通路/营养限制/电离辐射/基因组稳定Key words
Argopecten scallops/lifespan/IIS pathway/nutritional restriction/ionizing radiation/genomic stability分类
海洋科学引用本文复制引用
张泽斌,姜楠,唐永政,王春德,卢霞..Argopecten属海湾扇贝和紫扇贝的寿命调控机制[J].海洋科学,2025,49(3):116-125,10.基金项目
国家自然科学基金资助项目(42276147,31972791) （42276147,31972791）
山东省重点研发计划项目(2023ZGCQY006) （2023ZGCQY006）
山东省贝类产业技术体系遗传育种岗位专家项目(SDAIT-14)the National Natural Science Foundation of China,Nos.42276147,31972791 （SDAIT-14）
Key Research and Development Program of Shan-dong Province,No.2023ZGCQY006 （）
Earmarked Fund for Shandong Modern Agro-Industry Technology Research System,No.SDAIT-14 （）
