江西科学2025，Vol.43Issue(4)：717-724,8.DOI:10.13990/j.issn1001-3679.2025.04.020
N,N'-双辛基咪唑氮杂环卡宾银/金配合物的合成和抗金黄色葡萄球菌研究
Synthesis and Anti-Staphylococcus Aureus Activity of N,N'-Dioctylimidazolium-Based N-Heterocyclic Carbene Silver/Gold Complexes
摘要
Abstract
Objective:N-heterocyclic carbene(NHC)-gold(I)(C8Au)and NHC-silver(I)(C8Ag)complexes were synthesized using 1,3-dioctylimidazolium ionic liquid as a precur-sor.Their antibacterial activities were evaluated,particularly against Staphylococcus au-reus.Methods:The structures of the complexes were characterized by 1H-NMR and HRMS.Their antimicrobial activity and safety were assessed through minimum inhibitory concentration(MIC),time-kill assay,biofilm inhibition and eradication assays,drug re-sistance tests,checkerboard synergy assays,and a Galleria mellonella larvae model.Re-sults:C8Ag demonstrated significantly superior antibacterial activity against Staphylococcus aureus compared to C8Au,achieving rapid bactericidal effects within 2 hours.C8Ag also ex-hibited excellent biofilm inhibition and eradication capabilities,with a low tendency to induce drug resistance.Additionally,C8Ag showed strong synergistic effects when combined with various antibiotics.The Galleria mellonella larvae model confirmed the significant in vivo antibacterial efficacy and safety of C8Ag.Conclusion:The octyl chain-modified C8Ag com-plex exhibits significant antibacterial effects both in vitro and in vivo,demonstrating promis-ing potential for future applications.关键词
金黄色葡萄球菌/N-杂环卡宾银配合物/N-杂环卡宾金配合物/抗菌活性Key words
staphylococcus aureus/N-heterocyclic carbene silver complexes/N-heterocy-clic carbene gold complexes/antimicrobial activity分类
化学化工引用本文复制引用
黎海兰,朱菁,廖向文,王金涛..N,N'-双辛基咪唑氮杂环卡宾银/金配合物的合成和抗金黄色葡萄球菌研究[J].江西科学,2025,43(4):717-724,8.基金项目
国家自然科学基金项目(22067007) （22067007）
江西省自然科学基金项目(20242BAB23024). （20242BAB23024）
