摘要
Abstract
Objective To explore the clinicopathological characteristics,diagnostic key points and prognosis of localized tenosynovial giant cell tumour.Methods The clinical data of 25 patients diagnosed with localized tenosynovial giant cell tu-mour in Changping Hospital of Integrated Chinese and Western Medicine from 2011 to 2023 were collected.Histopathological observations and follow-up were conducted.The clinicopathological characteristics and prognosis were discussed in combination with relevant literature.Results Among the 25 patients,10 were male and 15 were female.The clinical symptoms of the 25 patients were mainly manifested as painless gradually increasing masses,and a few patients presented with varying degrees of tenderness or numbness of pain.The masses were located on the hands in 22 cases and on the feet in 3 cases.The maximum diameter ranged from 0.5 to 4 cm,and the surface was grayish yellow or grayish white.Under the light microscope,the tumor is mainly composed of round and polygonal synovioid monocytes,accompanied by varying numbers of osteoclavicular multinucleated giant cells,xanthoma cells,chronic inflammatory cells and hemosiderin.There is a distinct collagen matrix around the cells,and the collagen matrix shows varying degrees of hyaline degeneration.Among the 25 patients,the tumor cells grew actively in 8 cases,and mitotic images were easily seen in 2 cases(3-6/10 HPF).All cases underwent open surgery for complete resection of the tumor.Two cases were recurred.Conclusion Localized tenosynovial giant cell tumour is a rare benign lesion in clinical practice,prone to recurrence,and is most common in the hand.Clinically,it is generally manifested as a painless and slow-growing mass,and in some cases,varying degrees of tenderness or numbness may occur.The incidence rate is higher in women than in men.Diagnosis relies on pathological morphology.The treatment method is complete resection of the tumor.Recurrence may be related to the active growth of tumor cells and the easy visibility of mitotic images,etc.关键词
局限型腱鞘巨细胞瘤/临床特点/病理特征/复发Key words
Localized tenosynovial giant cell tumor/Clinical feature/Pathological feature/Recurrence分类
医药卫生
